The prevalence of neuropsychiatric symptoms and correlation with MRI findings in CADASIL patients.

Objective: To assess the prevalence, timing, and functional impact of neuropsychiatric symptoms in patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) and to assess whether these neuropsychiatric symptoms are associated with magnetic resonance imaging (MRI) features of the patients.

Methods: Our study included a total of 78 patients with CADASIL. To assess neuropsychiatric symptoms, we evaluated the caregivers using the Neuropsychiatric Inventory (NPI).

Tumor microenvironment activated mussel-inspired hollow mesoporous nanotheranostic for enhanced synergistic photodynamic/chemodynamic therapy.

Anti-tumor therapies reliant on reactive oxygen species (ROS) as primary therapeutic agents face challenges due to a limited oxygen substrate. Photodynamic therapy (PDT) is particularly hindered by inherent hypoxia, while chemodynamic therapy (CDT) encounters obstacles from insufficient endogenous hydrogen peroxide (HO) levels. In this study, we engineered biodegradable tumor microenvironment (TME)-activated hollow mesoporous MnO-based nanotheranostic agents, designated as HAMnOA.

Metal-Controlled Switchable Regioselective Synthesis of Substituted Imidazoles and Pyrroles Ring Opening/Cyclocondensation with 2-Azirines.

Catalytic selective annulation of 2-azirines constitutes a general and modular strategy for the generation of molecular complexity. By using Pd-catalyzed ring opening/heterocyclization associated with direct cleavage of C-N and C-C bonds under appropriate conditions, the formation of imidazoles is presented. Alternatively, the silver-catalyzed radical [3 + 2] cycloannulation of 2-azirines and 1,3-dicarbonyl compounds provides highly functionalized pyrrole derivatives.