Wearable optical coherence tomography angiography probe with extended depth of field.

Significance: Optical coherence tomography (OCT) is widely utilized to investigate brain activities and disorders in anesthetized or restrained rodents. However, anesthesia can alter several physiological parameters, leading to findings that might not fully represent the true physiological state. To advance the understanding of brain function in awake and freely moving animals, the development of wearable OCT probes is crucial.

Conventional magnetic resonance imaging combined with three-dimensional ultrasound for preoperative prediction of immediate ablation rate in high-intensity focused ultrasound treatment of uterine fibroids.

Objective: This study aimed to assess the effectiveness of conventional magnetic resonance imaging (MRI) combined with three-dimensional (3D) ultrasound for the preoperative prediction of nonperfused volume ratio (NPVR) in uterine fibroids after high-intensity focused ultrasound (HIFU) ablation.

Materials And Methods: In total, 178 patients who had undergone HIFU ablation therapy for uterine fibroids between July 2021 and August 2023 were enrolled. Baseline clinical, MRI, and 3D ultrasound parameters collected before and after HIFU ablation were analyzed.

Construction of a nomogram model to predict the risk of retinopathy of prematurity reactivate after intravitreal anti-vascular endothelial growth factor therapy: a retrospective study.

Objective: To explore the risk factors for the reactivate of retinopathy of prematurity (ROP) after intravitreal injection of anti-vascular endothelial growth factor (VEGF) and to construct a nomogram model to predict the risk of ROP reactivate.

Methods: A retrospective analysis was conducted on 185 ROP children who underwent anti-VEGF treatment at the First Affiliated Hospital of Zhengzhou University from January 2017 to October 2023. They were randomly divided into a training set (129 cases) and a validation set (56 cases) at a ratio of 7:3.

Impact of age of onset on the course of chronic schizophrenia: factors associated with first hospitalization in a large-scale cross-sectional study.

This study aims to identify the factors influencing the age of first hospitalization in patients with chronic schizophrenia, focusing on clinical features and blood parameters. A total of 1271 patients diagnosed with chronic schizophrenia were recruited from 17 psychiatric hospitals across China. Demographic and clinical data, including age of first hospitalization, were collected.

Gravity-Driven Ultrahigh-Speed Electrospinning for the Production of Ethyl Cellulose Fibers with Tunable Porosity for Oil Absorption.

Ethyl cellulose (EC) is a biocompatible, renewable, and recyclable material with diverse sources, making it an attractive candidate for industrial applications. Electrospinning has gained significant attention for the production of EC fibers. However, conventional electrospinning methods face challenges such as bead formation, low yield, and the absence of porous internal structures, limiting both the functional performance and scalability.

Prevalence and correlates of severe anxiety among front-line nurses during and after the COVID-19 pandemic: a large-scale multi-center study.

Background: Nurses have been at the forefront of the battle against the COVID-19 pandemic, facing extended work hours and heightened stress, predisposing them to psychological distress. This study aims to investigate the prevalence and correlates of severe anxiety among frontline nurses in China during and after the COVID-19 pandemic.

Methods: A large-scale multi-center survey was conducted from November to December 2022 and from April to July 2023.

Observation of complete energy transfer by orthogonally polarized Raman scattering in a high-birefringence fiber.

This study reports the observation of complete orthogonally polarized Raman scattering (OPRS) in a 1.0-km high-birefringence fiber (HBF). An incident pump pulse at 1560 nm with an energy of 2.

Years of life lost attributable to air pollution, a health risk-based air quality index approach in Ningbo, China.

Air pollution remains a significant threat to human health and economic development. Most previous studies have examined the health effects of individual pollutants, which often overlook the combined impacts of multiple pollutants. The traditional composite indicator air quality index (AQI) only focuses on the major pollutants, whereas the health risk-based air quality index (HAQI) could offer a more comprehensive evaluation of the health effects of various pollutants on populations.

Antiviral Medications for Treatment of Nonsevere Influenza: A Systematic Review and Network Meta-Analysis.

Importance: The optimal antiviral drug for treatment of nonsevere influenza remains unclear.

Objective: To compare effects of antiviral drugs for treating nonsevere influenza.

Data Sources: MEDLINE, Embase, CENTRAL, CINAHL, Global Health, Epistemonikos, and ClinicalTrials.

Uncovering the role of the Cr dopant in RuO in highly efficient acid water oxidation.

The design of acidic oxygen evolution reaction (OER) electrocatalysts with high activity and durability is the key to achieving efficient hydrogen production. Herein, we report a Cr-doped RuO (RuCrO) catalyst that exhibits good OER activity in acidic electrolytes. The doping of Cr increases the valence state of Ru, which enhances the activity of the catalyst, and a current density of 10 mA cm can be achieved at only 235 mV, which is superior to that of unmodified RuO of 299 mV.

End-to-End Multi-Scale Adaptive Remote Sensing Image Dehazing Network.

Satellites frequently encounter atmospheric haze during imaging, leading to the loss of detailed information in remote sensing images and significantly compromising image quality. This detailed information is crucial for applications such as Earth observation and environmental monitoring. In response to the above issues, this paper proposes an end-to-end multi-scale adaptive feature extraction method for remote sensing image dehazing (MSD-Net).

[Efficacy and learning curve of 69 cases of robot-assisted resection of retroperitoneal benign tumors].

To explore the efficacy of robotic-assisted retroperitoneal benign tumor resection and to analyze its learning curve. This is a retrospective case series study. The data of patients who underwent robotic-assisted retroperitoneal benign tumor resection from August 2015 to February 2023 at the Department of Retroperitoneal Tumor Surgery was analyzed retrospectively.

Hypoxic BMSC-derived exosomal miR-210-3p promotes progression of triple-negative breast cancer cells via NFIX-Wnt/β-catenin signaling axis.

Background: Bone marrow mesenchymal stem cells (BMSCs) are a crucial component of the tumor microenvironment (TME), with hypoxic conditions promoting their migration to tumors. Exosomes play a vital role in cell-to-cell communication within the TME. Hypoxic TME have a great impact on the release, uptake and biofunctions of exosomes.

Genomic insights into fibrinogen-related proteins and expression analysis in the Pacific white shrimp, Litopenaeusvannamei.

Fibrinogen-related domain (FReD) containing proteins are an evolutionarily conserved immune gene family characterized by the C-terminal fibrinogen (FBG) and diverse N-terminal domains. To understand the complexity of this family in crustaceans, we performed genome screening and identified 43 full-length FReDs encoding genes in Litopenaeus vannamei. Structural classification analysis revealed these putative FReDs could be divided into six types, including two reported types (LvFReDI and II) and four new types (LvFReDIII-VI).

Inhibition of METTL14 overcomes CDK4/6 inhibitor resistance driven by METTL14-m6A-E2F1-axis in ERα-positive breast cancer.

CDK4/6i, the first-line drug for treating ERα-positive breast cancer, significantly improves clinical outcomes. However, CDK4/6i resistance often develops and remains a major hurdle, and the underlying mechanisms remain challenging to fully investigate. Here, we used Genome-wide CRISPR/Cas9 library screening combined with single-cell sequencing to screen for molecules mediating CDK4/6i resistance and identified METTL14 as a determinant of CDK4/6i sensitivity.

Breaking through Electrospinning Limitations: Liquid-Assisted Ultrahigh-Speed Production of Polyacrylonitrile Nanofibers.

Carbon-based nanofibers are critical materials with broad applications in industries such as energy, filtration, and biomedical devices. Polyacrylonitrile (PAN) is a primary precursor for carbon nanofibers, but conventional electrospinning techniques typically operate at low production rates of 0.1-1 mL/h from a single spinneret, limiting scalability.

Eye-Inspired Single-Pixel Imaging with Lateral Inhibition and Variable Resolution for Special Unmanned Vehicle Applications in Tunnel Inspection.

This study presents a cutting-edge imaging technique for special unmanned vehicles (UAVs) designed to enhance tunnel inspection capabilities. This technique integrates ghost imaging inspired by the human visual system with lateral inhibition and variable resolution to improve environmental perception in challenging conditions, such as poor lighting and dust. By emulating the high-resolution foveal vision of the human eye, this method significantly enhances the efficiency and quality of image reconstruction for fine targets within the region of interest (ROI).

Higher CSF sTREM2 attenuates APOE ε4-related risk for amyloid pathology in cognitively intact adults: The CABLE study.

The triggering receptor expressed on myeloid cells 2 (TREM2) is a transmembrane protein found in microglia within the brain, and its soluble form (sTREM2) has been shown to reduce amyloid deposition. Whether elevated TREM2-mediated microglial activity decreases the risk of Alzheimer's disease (AD) is unclear. The aim of this study was to assess whether high cerebrospinal fluid (CSF) levels of sTREM2 attenuate the risk of APOE ε4-associated amyloid pathology.

Synovial mast cells and osteoarthritis: Current understandings and future perspectives.

Osteoarthritis (OA) is a prevalent joint disease worldwide that significantly impacts the quality of life of individuals, particularly those in middle-aged and elderly populations. OA was initially considered as non-inflammatory arthritis, but recent studies have identified a substantial number of immune responses in OA, leading to the recognition of inflammation as a key factor in its pathogenesis. An increasing number of studies have found that mast cell (MC) and MC-secreted inflammatory mediators and cytokines are notably increased in the synovial fluid of OA patients, indicating a potential association between MCs and the onset and progression of synovial inflammation.

Lymphatic plastic bronchitis: a study based on CT and MR lymphangiography.

Objectives: To investigate the diagnostic value of CT lymphangiography (CTL) and non-contrast MR lymphangiography (MRL) in lymphatic plastic bronchitis.

Materials And Methods: The clinical and imaging data of 31 patients with lymphatic plastic bronchitis diagnosed by clinical, imaging and pathological results were retrospectively analyzed. All patients underwent CTL and MRL.

SLC25A21 correlates with the prognosis of adult acute myeloid leukemia through inhibiting the growth of leukemia cells via downregulating CXCL8.

In recent years, targeting mitochondrial apoptosis has emerged as a promising therapeutic strategy for Acute Myeloid Leukemia (AML). The SLC25 family of mitochondrial carriers plays a critical role in maintaining mitochondrial function and regulating apoptosis. However, the role of SLC25A21, an oxodicarboxylate carrier, in AML progression and its potential as a prognostic biomarker remain underexplored.

Effects of cardiac contractility modulation on autophagy and apoptosis of cardiac myocytes in rabbits with chronic heart failure.

Background: Cardiac contractility modulation (CCM) is non-excitatory electrical stimulation for improving cardiac function. This study aimed to evaluate the effects of CCM on autophagy and apoptosis of cardiac myocytes in a rabbit model of chronic heart failure (CHF) and explore its possible mechanism.

Methods: Thirty rabbits were randomised into the Sham, heart failure (HF) and CCM groups, and animals in all three groups were sacrificed after 16 weeks of ascending aortic constriction or sham surgery.

Case Report: A young man with frontal traumatic sinus pericranii.

Sinus pericranii is a rare venous anomaly characterized by abnormal communication between intracranial and subperiosteal veins, and reports of trauma-induced sinus pericranii are even rarer. Herein, we report a case of delayed-onset sinus pericranii resulting from a traumatic injury to the left side of the midline of the forehead sustained in early childhood. The anomaly was successfully resected via a coronal incision within the hairline, followed by meticulous bone wax sealing.