Does preventive external ventricular drainage benefit patients with mild ventricular hemorrhage?

External ventricular drainage (EVD) is the routine intraventricular hemorrhage (IVH) treatment. Neurological deterioration and symptomatic hydrocephalus are often the default indications for EVD insertion. However, the outcome of preventive EVD is unclear in patients with mild IVH.

Discrete Element Study on Bending Resistance of Geogrid Reinforced Cement-Treated Sand.

Cement-treated sand reinforced with geogrids (CTSGs) has higher bending resistance and toughness than cement-treated sands (CTSs). To explore the reinforcement mechanism of geogrids with different stiffness and layers on CTSGs, three-point bending tests and numerical tests based on DEM are carried out on CTS specimens and CTSG specimens considering different reinforcement conditions. The results show that the geogrids and cement-treated sands have good cooperative working performance.

SDMT: Spatial Dependence Multi-Task Transformer Network for 3D Knee MRI Segmentation and Landmark Localization.

Knee segmentation and landmark localization from 3D MRI are two significant tasks for diagnosis and treatment of knee diseases. With the development of deep learning, Convolutional Neural Network (CNN) based methods have become the mainstream. However, the existing CNN methods are mostly single-task methods.

An Integrated Multitasking Intelligent Bearing Fault Diagnosis Scheme Based on Representation Learning Under Imbalanced Sample Condition.

Accurate bearing fault diagnosis is of great significance of the safety and reliability of rotary mechanical system. In practice, the sample proportion between faulty data and healthy data in rotating mechanical system is imbalanced. Furthermore, there are commonalities between the bearing fault detection, classification, and identification tasks.

Mycotoxin risk management in maize gluten meal.

Maize gluten meal (MGM) is a by-product of maize starch and ethanol, produced by the wet milling process. Its high protein content makes it a preferred ingredient in feed. Given the high prevalence of mycotoxins in maize globally, they pose a significant challenge to use of MGM for feed: wet milling could concentrate certain mycotoxins in gluten components, and mycotoxin consumption affects animal health and can contaminate animal-source foods.

Effects of polishing press-on force on surface roughness and gloss of CAD-CAM composites.

Purpose: The aim of this study was to determine the effect of polishing press-on force on surface roughness and gloss of computer-aided design-computer-aided manufacturing (CAD-CAM) composites.

Methods: The materials evaluated included a CAD-CAM ceramic, a polymer-infiltrated ceramic, and three filler-based CAD-CAM composites. The CAD-CAM blocks were sectioned, embedded in self-cured resin, finished with abrasive papers and ultrasonically cleaned.

Glycerol Droplet Spreading on Growing Bacillus Subtilis Biofilms.

Bacterial biofilm is a three-dimensional matrix composed of a large number of living bacterial individuals. The strong bio-interaction between the bacteria and its self-secreted matrix environment strengthens the mechanical integrity of the biofilm and the sustainable resistance of bacteria to antibiotics. As a soft surface, the biofilm is expected to present different dynamical wetting behavior in response to shear stress, which is, however, less known.

The Role of Contextual Factors in Shaping Urban Older Adults' Intention of Institutional Care in China: A Mixed-Methods Study.

Background: This mixed-methods study explores older people's intention of institutional care and its contributing contextual factors, and the meaning given to their intention by older adults in the transitioning Chinese society.

Methods: Guided by the extended Anderson model and frameworks of the ecological theory of aging, survey data collected from 1937 Chinese older adults were used. Transcripts from six focus group interviews were analyzed to incorporate the voices of the participants.

Human-Machine Interaction via Dual Modes of Voice and Gesture Enabled by Triboelectric Nanogenerator and Machine Learning.

With the development of science and technology, human-machine interaction has brought great benefits to the society. Here, we design a voice and gesture signal translator (VGST), which can translate natural actions into electrical signals and realize efficient communication in human-machine interface. By spraying silk protein on the copper of the device, the VGST can achieve improved output and a wide frequency response of 20-2000 Hz with a high sensitivity of 167 mV/dB, and the resolution of frequency detection can reach 0.

Manipulation of the photoluminescence of lead halide perovskite quantum dots with mechanically reconfigurable 3D photonic crystals.

Reconfigurable 3D photonic crystals (3DPCs) are promising for dynamic emission devices, owing to their unique properties. Here, we integrated the perovskite quantum dot film together with 3D reconfigurable photonic crystals (PCs) to form quantum dot/photonic crystal heterostructures and investigated their interactions at their interfaces. The photonic bandgaps of the presented 3DPCs can be dynamically tuned by heating and applying external mechanical forces, and they can be stably fixed in the intermediate states.

Creating a semi-opened micro-cavity ovary through sacrificial microspheres as an model for discovering the potential effect of ovarian toxic agents.

The bio-engineered ovary is an essential technology for treating female infertility. Especially the development of relevant models could be a critical step in a drug study. Herein, we develop a semi-opened culturing system (SOCS) strategy that maintains a 3D structure of follicles during the culture.

Long non-coding RNA LINC01480 is activated by Foxo3a and promotes hydroquinone-induced TK6 cell apoptosis by inhibiting the PI3K/AKT pathway.

Long non-coding RNAs (lncRNAs) have been shown to play a critical role in the damage caused to the body by environmental exogenous chemicals; however, few studies have explored their effects during exposure to benzene and its metabolite, hydroquinone (HQ). An emerging lncRNA, LINC01480, was found to be associated with the immune microenvironment of some cancers, but its specific function remains unknown. Therefore, this study aimed to investigate the role of LINC01480 in HQ-induced apoptosis.

Swimming of Buoyant Bacteria in Quiescent Medium and Shear Flows.

Gravity has an unavoidable effect on all living organisms inhabiting fluidic surroundings. To investigate the spatial distribution of bacteria in quiescent fluids and their rheotactic behavior in shear flows under buoyancy, we adjust the buoyant force to regulate bacterial swimming in a microfluidic channel. It is found that swimming bacteria of exhibit an obvious vertical separation when exposed to a medium with high density and gradually gather close to the up wall within minutes.

Treatment-resistant depression and risk of autoimmune diseases: evidence from a population-based cohort and nested case-control study.

Recent literature indicates that patients with depression had increased immune activation. We hypothesised that treatment-resistant depression (TRD), an indicator of non-responsive depression with long-term dysregulated inflammation, could be an independent risk factor for subsequent autoimmune diseases. We performed a cohort study and a nested case-control study to examine the association between TRD and risk of autoimmune diseases, and to explore potential sex-specific difference.

Bioengineered omental transplant site promotes pancreatic islet allografts survival in non-human primates.

The transplanting islets to the liver approach suffers from an immediate posttransplant loss of islets of more than 50%, progressive graft dysfunction over time, and precludes recovery of grafts should there be serious complications such as the development of teratomas with grafts that are stem cell-derived islets (SC-islets). The omentum features an attractive extrahepatic alternative site for clinical islet transplantation. We explore an approach in which allogeneic islets are transplanted onto the omentum, which is bioengineered with a plasma-thrombin biodegradable matrix in three diabetic non-human primates (NHPs).

Evaluation of multiplex nanopore sequencing for serotype prediction and antimicrobial resistance gene and virulence gene detection.

In a previous study, Multiplex-nanopore-sequencing based whole genome sequencing (WGS) allowed for accurate serotype prediction of within one day for five multiplexed isolates, using both SISTR and SeqSero2. Since only ten serotypes were tested in our previous study, the conclusions above were yet to be evaluated in a larger scale test. In the current study we evaluated this workflow with 69 serotypes and also explored the feasibility of using multiplex-nanopore-sequencing based WGS for antimicrobial resistance gene (AMR) and virulence gene detection.

Kinome-wide polypharmacology profiling of small molecules by multi-task graph isomorphism network approach.

Prediction of the interactions between small molecules and their targets play important roles in various applications of drug development, such as lead discovery, drug repurposing and elucidation of potential drug side effects. Therefore, a variety of machine learning-based models have been developed to predict these interactions. In this study, a model called auxiliary multi-task graph isomorphism network with uncertainty weighting (AMGU) was developed to predict the inhibitory activities of small molecules against 204 different kinases based on the multi-task Graph Isomorphism Network (MT-GIN) with the auxiliary learning and uncertainty weighting strategy.

Zeolites as a Class of Semiconductors for High-Performance Electrically Transduced Sensing.

Zeolites are widely used as catalysts and adsorbents in the chemical industry, but their potential for electronic devices has been stunted to date, as they are commonly recognized as electronic insulators. Here, we have for the first time demonstrated that Na-type ZSM-5 zeolites are ultrawide-direct-band-gap semiconductors based on optical spectroscopy, variable-temperature current-voltage characteristics, and photoelectric effect as well as electronic structure theoretical calculations and further unraveled the band-like charge transport mechanism in electrically conductive zeolites. The increase in charge-compensating Na cations in Na-ZSM-5 decreases the band gap and affects its density of states, shifting the Fermi level close to the conduction band.

MsgeCNN: Multiscale geometric embedded convolutional neural network for ONFH segmentation and grading.

Background: The incidence of osteonecrosis of the femoral head (ONFH) is increasing gradually, rapid and accurate grading of ONFH is critical. The existing Steinberg staging criteria grades ONFH according to the proportion of necrosis area to femoral head area.

Purpose: In the clinical practice, the necrosis region and femoral head region are mainly estimated by the observation and experience of doctor.

Vital node identification based on cycle structure in a multiplex network.

Abstract: Multiplex networks frame the heterogeneous nature of real systems, where the multiple roles of nodes, both functionally and structurally, are well represented. We identify these vital nodes in a multiplex network so that we can control a pandemic outbreak like COVID-19, eliminate damage from a network attack, maintain traffic, and so on. Vital node identification has attracted scientists in various fields for decades.

Removal of Sulfide Ions from Kraft Washing Effluents by Photocatalysis with N and Fe Codoped Carbon Dots.

N and Fe codoped carbon dots (N,Fe-CDs) were fabricated from citric acid, L-glutamic acid and ferric chloride via a hydrothermal method for the photocatalytic removal of S from kraft washing effluents (KWE). The N,Fe-CDs were fluorescent nanoparticles (average size of 3.18 nm) and catalyzed the oxidation of S following a first-order kinetic model with an activation energy of 33.

SAMD9 Promotes Postoperative Recurrence of Esophageal Squamous Cell Carcinoma by Stimulating MYH9-Mediated GSK3β/β-Catenin Signaling.

Recurrence is a challenge to survival after the initial treatment of esophageal squamous cell carcinoma (ESCC). But, its mechanism remains elusive and there are currently no biomarkers to predict postoperative recurrence. Here, the possibility of sterile alpha motif domain-containing protein 9 (SAMD9) as a predictor of postoperative recurrence of ESCC is evaluated and the molecular mechanisms by which SAMD9 promotes ESCC recurrence are elucidated.

The Cuistow: A Modified Arthroscopic Bristow Procedure for the Treatment of Recurrent Anterior Shoulder Instability.

Unlabelled: The rate of nonunion observed among the variety of Bristow-Latarjet procedures reportedly ranges from 9.4% to 28%. In Chinese timber buildings, the mortise-tenon joint is commonly utilized to connect beams to columns.