177Lu-LNC1004 Radioligand Therapy in Patients with End-stage Metastatic Cancers: A Single-Center, Single-Arm, Phase II Study.

Purpose: Fibroblast activation protein (FAP) is highly expressed in cancer-associated fibroblasts and certain tumor cells, making it a promising therapeutic target for various malignancies. This study evaluated the efficacy and safety of 177Lu-Evans blue-FAP inhibitor (177Lu-LNC1004) radioligand therapy (RLT) for treating end-stage metastatic tumors.

Patients And Methods: This single-arm, single-center, phase II trial included 28 patients with progressive metastatic malignancies (11 types) and high FAP expression (defined as a maximum standardized uptake value ≥10 in >50% of tumors) who had exhausted all approved therapies, screened between June 2022 and April 2024.

MicroRNA-155 rs767649 polymorphism is associated with susceptibility to peri-implantitis.

Objective: To examine how the miR-155 rs767649 polymorphism affects miR-155 expression and to investigate its association with peri-implantitis susceptibility.

Design: One hundred and eighty-seven peri-implantitis patients and 196 healthy implant subjects were enrolled. The expression level of miR-155 in the subjects' serum was tested using qRT-PCR.

A sensitive electrochemical biosensor based on Exo III cyclic amplification strategy for Phaeocystis globosa detection.

Phaeocystis globosa (P. globosa), a main culprit of harmful algal blooms (HABs), is highly prone to blocking the inlet filter screens of nuclear power cold sources, thus posing a significant threat to nuclear power safety. However, existing methods for P.

Detection of toxoplasma tachyzoites in the cerebrospinal fluid of a COVID-19 positive SLE patient: a case study.

The recurrence of latent toxoplasmosis is a frequent cause of toxoplasmic encephalopathy in individuals with immunosuppressive conditions or medication. If left untreated or diagnosed is delayed, it often resulting in fatality. The pathogen of Toxoplasma gondii has been identified in cerebrospinal fluid cytology and a limited number of documented cases of cerebral toxoplasmosis, typically observed in those with acquired immunodeficiency syndrome (AIDS).

Surgical Intervention Improves Long-Term Survival in Stage IV Thymic Epithelial Tumors: Insights From a SEER Database Analysis.

Objectives: This research evaluates how surgical intervention affects survival rates in individuals with stage IV thymic epithelial tumors (TET) based on data from the SEER database, offering essential information for clinical decision making.

Methods: The SEER database (2004-2020) provided data on stage IV TET patients, classified into surgical and non-surgical groups. Analytical techniques, including propensity score matching (PSM) and inverse probability treatment weighting (IPTW), were employed.

Impact of BMPR2 mutation on the severity of pulmonary arterial hypertension: a systematic review and meta-analysis.

Objective: To evaluate the association between PAH severity in patients with and without BMPR2 mutation. Additionally, subgroup analyses were also performed to investigate whether differences existed among different ethnicities.

Methods: A literature search of the PubMed-MEDLINE, EMBASE, Web of Science, Scopus, and Cochrane Central Register of Controlled Trials databases was conducted from inception through June, 2024, to identify eligible studies.

A portable biosensor based on exonuclease III-assisted amplification strategy for on-site monitoring and early warning of Phaeocystis globosa bloom.

In recent years, the frequent outbreaks of Phaeocystis globosa (P. globosa) bloom have seriously threatened the safety of coastal nuclear power. However, existing detection technologies cannot meet the demand for the early warning of P.

Electrochemical biosensor based on strand displacement reaction for on-site detection of Skeletonema costatum.

An electrochemical biosensor was constructed for quantitatively detecting Skeletonema costatum (S. costatum) by combining the electrode modification material (NC-Au) with a strand displacement reaction (SDR). The SDR process addresses the issues of steric hindrance and electrostatic repulsion resulting from the large size of genomic DNA.

Development and multicenter validation of machine learning models for predicting postoperative pulmonary complications after neurosurgery.

Background: Postoperative pulmonary complications (PPCs) are major adverse events in neurosurgical patients. This study aimed to develop and validate machine learning models predicting PPCs after neurosurgery.

Methods: PPCs were defined according to the European Perioperative Clinical Outcome standards as occurring within 7 postoperative days.

Identifying risk factors for left ventricular thrombus in patients with ischemic left ventricular aneurysm using cardiac MRI.

Background: Ischemic left ventricular (LV) aneurysm is associated with LV thrombus and subsequent embolic events. However, there is currently no evidence-based recommendation for anticoagulation in these patients.

Objective: To determine the characteristics of LV aneurysms associated with a high risk of thrombus formation.

An Easy and Quick Risk-Stratified Early Forewarning Model for Septic Shock in the Intensive Care Unit: Development, Validation, and Interpretation Study.

Background: Septic shock (SS) is a syndrome with high mortality. Early forewarning and diagnosis of SS, which are critical in reducing mortality, are still challenging in clinical management.

Objective: We propose a simple and fast risk-stratified forewarning model for SS to help physicians recognize patients in time.

Effects of fructooligosaccharides and on the composition and metabolism of gut microbiota in students.

Fructooligosaccharides (FOSs) and have shown great potential in treating gastrointestinal diseases by regulating gut microbiota and metabolites. However, the synergistic effect between these two remains unclear. In this study, an fermentation model was constructed to investigate the regulatory effects of FOSs and on the gut microbiota of healthy student populations.

Targeted therapeutic strategy for oral squamous carcinoma using celecoxib-loaded GABA/wheat gluten-alginate nanocarrier hydrogel with glutathione down-regulation and enhanced CCND2-mediated apoptosis.

The intricate architecture of the oral cavity results in insufficient surgical excision of oral squamous cell carcinoma (OSCC) potentially increasing the risk of metastasis and recurrence during treatment. In situ generating injectable hydrogels, characterized by minimally invasive methods, encapsulating stability, and pH-responsive breakdown have emerged as viable delivery systems. Herein, we aim to explore a particular therapeutic modality involving the use of celecoxib-loaded GABA/wheat gluten‑sodium alginate (SA/WG-GABA+COX(40)) nanocarriers in enhancing apoptosis of OSCC (HSC-3 & SCC-25).

KNL1 recruits type one protein phosphatase to kinetochores to silence the spindle assembly checkpoint.

Proper chromosome segregation during cell division is essential for genomic integrity and organismal development. This process is monitored by the spindle assembly checkpoint (SAC), which delays anaphase onset until all chromosomes are properly attached to the mitotic spindle. The kinetochore protein KNL1 plays a critical role in recruiting SAC proteins.

Hierarchical Fe-based electrocatalyst for lattice oxygen mediated water oxidation with Industrial-Level activity.

Rational design transition metal-based electrocatalysts for oxygen evolution reaction (OER) at large current densities is vital for industrial applications of alkaline water electrolysis. Here, we present a three-dimensional catalyst comprises of FeO nanoparticles that are highly dispersed on FeMoO nanorods, supported on Ni foam, featuring a hierarchical heterostructure and array morphology. The resulting FeO/FeMoO/NF electrodes exhibit remarkable OER catalytic activity, achieving overpotentials of 315 mV and 352 mV at current densities of 1000 mA cm and 2000 mA cm, respectively, while maintaining outstanding long-term durability (>900 h) at a current density of 500 mA cm.

FAP-targeted PET/CT imaging in patients with breast cancer from a prospective bi-center study: insights into diagnosis and clinic management.

Purpose: To evaluate the diagnostic accuracy and clinical impact of fibroblast activation protein (FAP)-targeted PET/CT imaging in primary and metastatic breast cancer and compare the results with those of standard-of-care imaging (SCI) and [F]FDG PET/CT.

Methods: We prospectively analyzed patients with diagnosed or suspected breast cancer who underwent concomitant FAP-targeted PET/CT (radiotracers including either [Ga]Ga-FAPI-46 or [F]FAPI-42) and [F]FDG PET/CT scans from June 2020 to January 2024 at two medical centers. Breast ultrasound (US) imaging was performed in all treatment-naïve patients as SCI.

A potential therapeutic approach for ulcerative colitis: targeted regulation of mitochondrial dynamics and mitophagy through phytochemicals.

Mitochondria are important organelles that regulate cellular energy and biosynthesis, as well as maintain the body's response to environmental stress. Their dynamics and autophagy influence occurrence of cellular function, particularly under stressful conditions. They can generate reactive oxygen species (ROS) which is a major contributor to inflammatory diseases such as ulcerative colitis (UC).

Bilayer Mn-based Prussian blue cathode with high redox activity for boosting stable cycling in aqueous sodium-ion half/full batteries.

The Mn-based Prussian blue analogs (PBAs) have garnered significant attention due to their high specific capacity, stemming from the unique multi-electron reactions with Na. However, the structural instability caused by multi-ion insertion impacts the cycle life, thus limiting their further application in aqueous sodium-ion batteries (ASIBs). To address this issue, this work employed an in situ epitaxial solvent deposition method to homogeneously grow Ni hexacyanoferrate (NiHCF) on the surface of MnPBA, which can effectively overcome the de-intercalation instability.

Local Environment-Modulated f-f Transition in Unit-Cell-Sized Lanthanide Ultrathin Nanostructures.

The regulation of the f-f transition is the basis of utilizing the abundant optical properties of lanthanide (Ln), of which the key is to modulate the local environment of Ln ions. Here, we constructed Eu(III)-based unit-cell-sized ultrathin nanowires (UCNWs) with red luminescence and polymer-like behavior, which appears as an ideal carrier for regulating f-f transition. The f-f transition of Eu(III) in UCNWs could be precisely regulated through various ligands.

Chinese Herbal Medicine and Their Active Ingredients Involved in the Treatment of Atopic Dermatitis Related Signaling Pathways.

Atopic dermatitis (AD) is a common inflammatory dermatitis of the skin and poses therapeutic challenges due to the adverse reactions and high costs associated with available treatments. In Eastern Asian countries, a plethora of herbal remedies is extensively employed for the alleviation of AD. Many of these botanicals are renowned for their formidable anti-inflammatory properties, contributing to AD management.

Buried interface engineering towards stable zinc anodes for high-performance aqueous zinc-ion batteries.

The dendrite and corrosion issues still remain for zinc anodes. Interface modification of anodes has been widely used for stabilizing zinc anodes. However, it is still quite challenging for such modification to simultaneously suppress zinc dendrites and corrosion issues.

The potential role of vesicle transport-related small GTPases rabs in abiotic stress responses.

Rab GTPases are a class of small GTP-binding proteins, play crucial roles in the membrane transport machinery with in eukaryotic cells. They dynamically regulate the precise targeting and tethering of transport vesicles to specific compartments by transitioning between active and inactive states. In plants, Rab GTPases are classified into eight distinct subfamilies: Rab1/D, Rab2/B, Rab5/F, Rab6/H, Rab7/G, Rab8/E, Rab11/A, and Rab18/C.

Qualitative Transcriptional Signature for Predicting the Pathological Response of Colorectal Cancer to FOLFIRI Therapy.

FOLFIRI (5-FU, leucovorin, irinotecan) is the first-line chemotherapy for metastatic colorectal cancer (mCRC), but response rates are under 50%. This study aimed to develop a predictive signature for FOLFIRI response in mCRC patients. Firstly, Spearman's rank correlation and Wilcoxon rank-sum test were used to select chemotherapy response genes and gene pairs, respectively.