Prognostic significance of lymphovascular invasion in pN0 stage gastric cancer: a propensity score matching analysis.

Background: To explore the potential impact of lymphovascular invasion (LVI) on overall survival (OS) of pN0 stage gastric cancer (GC) after curative resection.

Methods: A total of 497 GC patients who underwent curative gastrectomy and postoperative pathology proved negative lymph node metastasis between January 2015 and December 2018 in our center were enrolled in this study. All patients were divided into two groups according to the status of LVI.

Qualitative Transcriptional Signature for Predicting the Pathological Response of Colorectal Cancer to FOLFIRI Therapy.

FOLFIRI (5-FU, leucovorin, irinotecan) is the first-line chemotherapy for metastatic colorectal cancer (mCRC), but response rates are under 50%. This study aimed to develop a predictive signature for FOLFIRI response in mCRC patients. Firstly, Spearman's rank correlation and Wilcoxon rank-sum test were used to select chemotherapy response genes and gene pairs, respectively.

Personalized federated learning for abdominal multi-organ segmentation based on frequency domain aggregation.

Purpose: The training of deep learning (DL) models in medical images requires large amounts of sensitive patient data. However, acquiring adequately labeled datasets is challenging because of the heavy workload of manual annotations and the stringent privacy protocols.

Methods: Federated learning (FL) provides an alternative approach in which a coalition of clients collaboratively trains models without exchanging the underlying datasets.

Boosting Enzyme-like Activities Atomization of Cerium for Tumor Microenvironment-Responsive Cascade Therapy.

Nanozyme catalytic therapeutic efficacy is limited by the finite enzyme activity and specificity. In this work, nitrogen-doped carbon loaded with a cerium single-atom nanozyme (Ce SAs@NC) is synthesized, exhibiting tumor specificity and excellent multiple enzyme-like activities. Compared with nitrogen-doped carbon loaded with CeO nanoparticles, Ce SAs@NC shows excellent peroxidase-like and catalase-like activity.

Causal relationship between major depressive disorder, anxiety disorder and constipation: a two-sample Mendelian randomization study.

Background: Epidemiological and other studies have shown correlations among major depressive disorder (MDD), anxiety disorder (AXD) and constipation. However, no consensus has been reached regarding their interdependence and pathogenesis. Herein, we sought to further explore the causal associations between them.

Foodborne pathogen detection using surface acoustic wave biosensors: a review.

This paper summarizes several attractive surface acoustic wave (SAW) biosensors, including Love-wave sensors, dual-channel SAW sensors, langasite SAW sensors, and SAW syringe filters. SAW sensors with different piezoelectric materials and high-frequency SAW sensors used for identifying the food pathogenic bacteria () are discussed together with the examples of methods based on such sensing technology that have been effectively utilized in diagnostics and epidemiological research. This review also emphasizes some of the limitations of using these biosensors, which have prompted the increased need for more rapid, sensitive, selective, portable, power-efficient, and low-cost methods for detecting these pathogens.

7-hydroxycoumarin ameliorates ulcerative colitis in mice by inhibiting the MAPK pathway and alleviating gut microbiota dysbiosis.

Objective: This research aimed to delineate the pharmacological mechanisms of 7-Hydroxycoumarin (7-HC) on ulcerative colitis (UC) employing network pharmacology and experimental validation.

Methods: To investigate the therapeutic effects of 7-HC on UC, a UC mouse model was established through the unrestricted intake of 3.0% dextran sulfate sodium (DSS) in their drinking water.

Comprehensive evaluation of freezing tolerance in prickly ash and its correlation with ecological and geographical origin factors.

Low temperatures are a key factor affecting the growth, development, and geographical distribution of prickly ash. This study investigated the impact of ecological and geographical factors on the freezing tolerance of prickly ash germplasm. Thirty-seven germplasm samples from 18 different origins were collected, and their freezing tolerance was comprehensively evaluated.

Comparative Study of Different Inflammation Definition Methods of GLIM in the Diagnosis of Malnutrition in Patients with Acute Pancreatitis.

Purpose: This study aims to investigate the influence of the Global Leadership Initiative on Malnutrition (GLIM) on diagnosing malnutrition in acute pancreatitis (AP) based on various inflammatory criteria.

Patients And Methods: A total of 258 AP patients admitted to a large medical center between June 2019 and January 2022 were retrospectively analyzed. All patients underwent evaluation using the original GLIM and GLIM criteria based on C-reactive protein (CRP), albumin, neutrophil/lymphocyte ratio, and CRP/albumin ratio (CAR).

Unlocking the structure and cation synergistic modulation of Prussian blue analogues with double redox mechanism for improved aqueous nonmetallic ion storage.

Prussian blue analogs (PBAs) exhibit high energy density and a good electrochemical stability window in aqueous non-metallic ion batteries, which is conducive to achieving high energy output and stable operation. Additionally, their synthesis process is simple and environmentally friendly, meeting the demands of sustainable development. However, the poor conductivity, structural stability issues, and inadequate ion diffusion pathways limit their application in batteries.

Diversity analysis of panicle traits in Chinese prickly ash germplasm resources and their influence on its systematic classification.

This study aimed to reveal the diversity and variation in panicle traits of the Chinese prickly ash and clarify their influence on the its systematic classification to provide a theoretical basis and technical support for the efficient utilization of Chinese prickly ash germplasm resources and breeding. Sixteen panicle traits were identified from 35 Chinese prickly ash germplasm resources from 2021 to 2022. The diversity of these panicle traits and their role in the plant's systematic classification were studied using variance, correlation, cluster, and principal component analyses.