Interacting multi-channel topological boundary modes in a quantum Hall valley system.

Symmetry and topology are central to understanding quantum Hall ferromagnets (QHFMs), two-dimensional electronic phases with spontaneously broken spin or pseudospin symmetry whose wavefunctions also have topological properties. Domain walls between distinct broken-symmetry QHFM phases are predicted to host gapless one-dimensional modes-that is, quantum channels that emerge because of a topological change in the underlying electronic wavefunctions at such interfaces. Although various QHFMs have been identified in different materials, interacting electronic modes at these domain walls have not been probed.

Three-dimensional localization of point acoustic sources using a planar microphone array combined with beamforming.

This paper presents a beamforming-based acoustic imaging (BBAI) method employing a two-dimensional (2D) microphone array that not only can locate an acoustic source in the plane parallel to the array, but can also identify the distance between the source and array in the direction, denoted as the source depth, and thus provides three-dimensional (3D) localization ability. In this method, the acoustic field is reconstructed on virtual planes at different distances along the direction. The source depth is then determined according to the virtual plane providing the maximum response of the acoustic field.

XPD suppresses cell proliferation and migration via miR-29a-3p-Mdm2/PDGF-B axis in HCC.

Objective: The aim of this study was to investigate the role of XPD in migration and invasion of hepatocellular carcinoma (HCC) cells.

Methods: The expression of XPD and miR-29a-3p was examined by western blot and qRT-PCR, cell proliferation was detected by MTT assay, cell migration was detected by transwell assay. TargetScan was used to predict potential targets of miR-29a-3p.

Posterolateral decompression, bone graft fusion, posterior instrumentation, and local continuous chemotherapy in the surgical treatment of thoracic spinal tuberculosis.

To investigate the clinical efficacy of surgical treatment for thoracic spinal tuberculosis with kyphosis deformity via posterolateral debridement, fusion, posterior instrumentation and local continuous chemotherapy. A total of 25 patients with thoracic tuberculosis received surgery by posterolateral decompression, fusion, posterior instrumentation, and postural drainage with local continuous chemotherapy between June 2009 and October 2011. The clinical outcomes was evaluated using statistical analysis about deformity correction, bone fusion, neurologic status, and the visual analog score (VAS) and erythrocyte sedimentation rate (ESR).

A Quantitative Assessment of Sustainable Development Based on Relative Resource Carrying Capacity in Jiangsu Province of China.

Unbalanced development is an urgent issue that needs to be resolved in the sustainable development strategy of Jiangsu Province, which inhibits Jiangsu's industrial transformation and upgrading. A relative resource carrying capacity model is extended based on resource carrying capacity to analyze the resource carrying capacity of the different regions of Jiangsu Province. Three indicators of water resources, land resources, and energy resources are included in the natural resources.

Adsorption Properties and Mechanism of Cd in Water by Zr-containing Silica Residue Purification.

Zirconium (Zr)-containing silica residue purification (ZSR-P) discharged from industrial production of ZrOCl was used as an adsorbent, and CdCl solution was used as the simulated wastewater containing cadmium ions (Cd). The properties and mechanisms of ZSR-P absorbing Cd were studied. The results showed that ZSR-P had a good effect on the adsorption and removal of Cd in water.

Lanthanum phosphate/chitosan scaffolds enhance cytocompatibility and osteogenic efficiency via the Wnt/β-catenin pathway.

Background: Fabrication of porous scaffolds with great biocompatibility and osteoinductivity to promote bone defect healing has attracted extensive attention.

Methods: In a previous study, novel lanthanum phosphate (LaPO)/chitosan (CS) scaffolds were prepared by distributing 40- to 60-nm LaPO nanoparticles throughout plate-like CS films.

Results: Interconnected three dimensional (3D) macropores within the scaffolds increased the scaffold osteoconductivity, thereby promoting cell adhesion and bone tissue in-growth.

Silencing of Xeroderma Pigmentosum Group D Gene Promotes Hepatoma Cell Growth by Reducing P53 Expression.

BACKGROUND This study investigated the effect of xeroderma pigmentosum group D (XPD) silencing on the growth of hepatoma cells and assessed the mechanisms. MATERIAL AND METHODS XPD gene was silenced by siRNA in hepatoma cells. The experiments were randomly divided into a control group, a liposome control group, a negative control (NC) group, an XPD siRNA group, and an XPD siRNA + P53 inhibitor group.

Broadband near-infrared light source derived from Cr-doped phosphors and a blue LED chip.

NIR-emitting YAl(BO):Cr/Yb (YAB:Cr/Yb) and NaScSiO:Cr (BSSO:Cr) phosphors were demonstrated as luminescent converters for broadband NIR phosphor-converted LEDs (pc-LEDs). YAB:Cr/Yb phosphors show emissions in 670-800 nm (Cr emission) and 950-1050 nm (Yb emission) upon excitation at 450 nm. In the BSSO host, Cr ions occupy Sc sites with relatively weak crystal field, and thus a broadband Cr emission at longer wavelengths of 750-950 nm is found for BSSO:Cr phosphors.

Potential-Resolved Multicolor Electrochemiluminescence for Multiplex Immunoassay in a Single Sample.

Electrochemiluminescence (ECL) is a highly successful technique used in commercial immunoassays for clinical diagnosis. Developing an ECL-based multiplex immunoassay, with the potential to enable high-throughput detection of multiple biomarkers simultaneously, remains a current research interest yet is limited by a narrow choice of ECL luminophores. Herein we report the synthesis, photophysics, electrochemistry, and ECL of several new ruthenium(II) and iridium(III) complexes, three of which are eventually used as signal reporters for multiplex immunoassay.

[Effects of Lidocaine on the Rho/ROCK Signal Transduction of the Posterior Basilar Artery in Rabbit SAH].

Objective: To observe the expression of Rho/Rho-associated kinase (ROCK) signaling pathway in the basilar artery and the effect of lidocaine on this signaling pathway after subarachnoid hemorrhage (SAH) in rabbits.

Methods: 24 New Zealand white rabbits were randomly divided into sham operation (sham) group, SAH group, and occipital cisterna lidocaine (CD) group. There were 8 rabbits in each group.

Carotid arterial wall stiffness correlates positively with impedance of the umbilical and uterine arteries in women with preeclampsia.

Purpose: This study aimed to determine whether the stiffness of the arterial walls of women with preeclampsia (PE) differs from that of healthy controls and to evaluate its association with fetal and uterine artery Doppler variables and perinatal outcomes in PE.

Methods: We enrolled 30 women with PE and 30 normotensive pregnant women. Carotid artery stiffness and Doppler variables of the uterine, umbilical, and fetal middle cerebral arteries and the ductus venosus were measured in both groups.

Calibration and cross-laboratory implementation of scintillating screens for electron bunch charge determination.

We revise the calibration of scintillating screens commonly used to detect relativistic electron beams with low average current, e.g., from laser-plasma accelerators, based on new and expanded measurements that include higher charge density and different types of screens than previous work [Buck , Rev.

The modification and characterization of thermal-treated sericite by fluorosilicate.

In this article, the thermal-treated sericite was modified by both fluorosilicate and the combination of fluorosilicate and nitric acid in order to reduce its layer charge and gain cation exchange capabilities for the preparation of sericite/polymer nanocomposites. After several orthogonal experiments and single factor experiments, the optimal experimental conditions were set up and we found that the combination of nitric acid and fluorosilicate is much more effective than fluorosilicate alone. Chemical composition analysis showed Al was dissolved out from sericite and the dissolving amount is 65 mg/g under optimal experimental conditions.

Collagen type V a2 (COL5A2) is decreased in steroid-induced necrosis of the femoral head.

Collagen is essential for bone adhesion and formation. In the present study, proteomic analysis suggested that collagen type V a2 (COL5A2) was significantly decreased in the necrotic area of patients with steroid-induced necrosis of the femoral head (ONFH). , the effects of methylprednisolone (MP) on the proliferation and differentiation of human bone marrow-derived mesenchymal stem cells (hBMSCs) were investigated.

Electrochemical detection of Alzheimer's disease related substances in biofluids by silica nanochannel membrane modified glassy carbon electrodes.

Alzheimer's disease (AD) affects middle- and old-age populations, and causes loss of brain weight, degradation of brain functions and memory loss. So the fast and accurate detection of AD related markers is highly important in diagnosis. We report in this work the detection of Cu2+ and dopamine (DA), which are markers related to AD, by direct electrochemistry (DEC) and electrochemiluminescence (ECL) using a silica nanochannel membrane modified glassy carbon electrode (SNM/GCE).

Generation of an Rtel1-CreERT2 knock-in mouse model for lineage tracing RTEL1+ stem cells during development.

Regulator of telomere length 1 (RTEL1) DNA helicase has been demonstrated to be essential for the maintenance of telomeres and genomic stability. This function of RTEL1 could be required for protecting stem cells from genomic mutations as suggested by its selective expression in stem cell-zones, as well as by RTEL1 mutations identified in Hoyeraal-Hreidarsson syndrome, a severe dyskeratosis congenita that targets primarily stem cell compartments. As a first step to establish a role of RTEL1 in stem cells, we generated an Rtel1 mouse allele in which a tamoxifen-inducible Cre (CreERT2) cDNA was specifically knocked into the Rtel1 genomic locus and controlled by the endogenous Rtel1 regulatory elements.

miR-338-5p Regulates the Viability, Proliferation, Apoptosis and Migration of Rheumatoid Arthritis Fibroblast-Like Synoviocytes by Targeting NFAT5.

Background/aims: MicroRNAs (miRNAs) have been reported to be involved in Rheumatoid arthritis (RA) pathogenesis and prognosis. However, little is known about the disease mechanism in RA. Here, we aim to investigate the potential association between miR-338-5p and NFAT5 in RA.

Rational civil servant interviewers: evidence from an event-related potential study of beauty premiums in Chinese civil servant interviews.

Physical attractiveness can greatly influence business job applications (the "beauty premium" effect). However, little is known about whether and how physical attractiveness influences interviewers' evaluations of Chinese civil servant applicants, given that many characteristics of civil service appear to be different from those of business jobs. Using event-related potentials (ERPs), the current study investigated how female job candidates' physical attractiveness influenced interviewers' evaluations in Chinese civil servant interviews for both technical and managerial positions.

Posterior surgical treatment of ankylosing spondylitis with spinal tuberculosis: A case series and long-term follow-up.

This retrospective cohort study aimed to evaluate the clinical outcomes of posterior surgical treatment of ankylosing spondylitis (AS) with spinal tuberculosis (STB). This was a retrospective study including 12 patients treated between January 2004 and April 2014 for AS with STB at our department. All patients underwent 1-stage posterior internal fixation, debridement, and bone fusion.

One-stage surgical management for lumber brucella spondylitis with anterior debridement, autogenous graft, and instrumentation.

Literature reporting on lumber brucella spondylitis (LBS) is rare, therefore, the purpose of this study was to evaluate the outcomes of one-stage surgical management for lumber brucella spondylitis by anterior debridement, autogenous grafts, and instrumentation. This was a retrospective cohort study including 16 patients with lumber brucella spondylitis by treated from January 2009 to October 2011 in our department. All cases underwent one-stage anterior internal fixation, debridement, and bone fusion; clinical and radiographic results were analyzed and compared.

Genes Influence the Virulence of Cryptococcus neoformans through Contributions beyond Core Autophagy Functions.

The process of autophagy is conserved among all eukaryotes from yeast to humans and is mainly responsible for bulk degradation of cellular contents and nutrient recycling during starvation. Autophagy has been suggested to play a role in the pathogenesis of the opportunistic human fungal pathogen , potentially through a contribution to the export of virulence factors. In this study, we showed that deletion of each of the , , , and genes in leads to autophagy-related phenotypes, including impaired amino acid homeostasis under nitrogen starvation.

The clinical outcomes and surgical strategy for cervical spine tuberculosis: A retrospective study in 78 cases.

Literature on the treatment of cervical spinal tuberculosis (CSTB) is uncommon, the surgical approaches to cervical spinal tuberculosis were controversial. The aim of the study was to evaluate the clinical outcomes of 3 surgical techniques in CSTB patients, and to determine the most appropriate approach for CSTB patients. Between April 2006 and June 2012, we performed a retrospective review of clinical and radiographic data that were collected from 850 consecutive spinal tubercular patients, including 87 patients who were diagnosed and treated for CSTB in our hospital.

Preparation of CaCO₃-TiO₂ Composite Particles and Their Pigment Properties.

CaCO₃-TiO₂ composite particles were prepared with calcium carbonate (CaCO₃) and TiO₂ in stirred mill according the wet grinding method. The pigment properties, morphology, and structure of CaCO₃-TiO₂ composite particles and the interaction behaviors between CaCO₃ and TiO₂ particles were explored. In the CaCO₃-TiO₂ composite particles, TiO₂ is uniformly coated on the surface of CaCO₃ and the firm combination between CaCO₃ and TiO₂ particles is induced by the dehydration reaction of surface hydroxyl groups.