The Role of the Cytoskeletal Regulatory Protein, Mammalian Enabling Protein (Mena), in Invasion and Metastasis of HPV16-Related Oral Squamous Cell Carcinoma.

Background: The objective of this study was to investigate the effect of mammalian-enabled protein (Mena) on invasion and metastasis of HPV16-related oral squamous cell carcinoma (OSCC) and the underlying mechanism.

Materials And Methods: The Mena gene expression profile of HPV-related OSCC was analyzed from the TCGA, GEO and TIMER databases. Immunohistochemistry was performed to study Mena, and the expression of invasion and metastasis-related markers and their clinicopathological characteristics.

Discovery of -Phenyl-5-propyl-1-pyrazole-3-carboxamide, with Selective Inhibition and Degradation of HDAC6 for the Treatment of Acute Liver Injury.

Acute liver injury is a severe and potentially life-threatening condition. Currently, there are no specific effective treatments available. HDAC6 has been identified as a promising strategy for treating ALI by inhibiting necrosis and inflammation.

Electric Field-Induced Synergetic Enhancement of Local Hydroxyl Concentration and Photogenerated Carrier Density for Removal of CO in Electrocatalytic Formic Acid Oxidation.

Direct formic acid fuel cell (DFAFC) is an efficient power generation device, due to its high energy density, low fuel crossover and low emission. However, the anodic reaction of DFAFC, formic acid oxidation (FAOR), inevitably proceeds through an indirect pathway, adsorbing carbon monoxide intermediate (CO), resulting in a rapid decline of activity for FAOR. Therefore, effectively removing CO is the key to the development of DFAFC.

p-n-Type LaCoO/NiFe LDH Heterostructures for Enhanced Photogenerated Carrier-Assisted Electrocatalytic Oxygen Evolution Reaction.

The oxygen evolution reaction (OER) poses a significant kinetic challenge for various critical energy conversion and storage technologies including electrocatalytic water splitting and metal-air batteries. In this study, a LaCoO/NiFe layered double hydroxide (LDH) catalyst was synthesized through the growth of n-type NiFe LDH on the surface of the p-type LaCoO semiconductor, resulting in a p-n heterostructure for a photogenerated carrier-assisted electrocatalytic OER (PCA-eOER). The alignment of their band structures facilitates the formation of an internal electric field at the heterojunction interface, which promotes the creation of oxygen vacancies and enhances electron transport.

Manipulating Trimetal Catalytic Activities for Efficient Urea Electrooxidation-Coupled Hydrogen Production at Ampere-Level Current Densities.

Replacing the oxygen evolution reaction (OER) with the urea oxidation reaction (UOR) in conjunction with the hydrogen evolution reaction (HER) offers a feasible and environmentally friendly approach for handling urea-rich wastewater and generating energy-saving hydrogen. However, the deactivation and detachment of active sites in powder electrocatalysts reported hitherto present significant challenges to achieving high efficiency and sustainability in energy-saving hydrogen production. Herein, a self-supported bimetallic nickel manganese metal-organic framework (NiMn-MOF) nanosheet and its derived heterostructure composed of NiMn-MOF decorated with ultrafine Pt nanocrystals (Pt/NiMn-MOF) are rationally designed.

Accurate loss measurement of optical bulk materials with the pulsed cavity ring-down technique.

In a wide range of laser applications, the optical losses of optical materials used in the laser systems are closely linked to the laser-induced damage and laser beam quality deterioration. It is demonstrated in this paper that when the pulsed cavity ring-down (CRD) technique is employed to measure the optical loss of uncoated substrates inserted in the ring-down cavity with normal incidence, the surface reflection of the uncoated substrate causes a significant overestimation of the optical loss. The degree of overestimation increases rapidly with the increasing surface reflectance.

AI-enhanced collective intelligence.

Current societal challenges exceed the capacity of humans operating either alone or collectively. As AI evolves, its role within human collectives will vary from an assistive tool to a participatory member. Humans and AI possess complementary capabilities that, together, can surpass the collective intelligence of either humans or AI in isolation.

Monocyte programmed death-ligand 1 upregulation in early post-out-of-hospital cardiac arrest is associated with increased risk of acute respiratory distress syndrome.

Background: Out-of-hospital cardiac arrest (OHCA) is a major public health problem. Acute respiratory distress syndrome (ARDS) is a common condition in OHCA patients. We investigated the relationship between the expression of programmed death-1 (PD-1) related molecules and the development and prognosis of ARDS.

Theoretical Study of Gas Sensing toward Acetone by a Single-Atom Transition Metal (Sc, Ti, V, and Cr)-Doped InP Monolayer.

Acetone (CHO) gas in the exhaled breath of diabetic patients can be used as an important biomarker for the painless and noninvasive diagnosis of diabetes mellitus. In this paper, based on the density functional theory (DFT), the adsorption behaviors of pristine and single-atom transition metal (X = Sc, Ti, V, and Cr)-doped InP surfaces (denoted as X-InP) toward CHO molecule were examined to explore the potential of these two-dimensional (2D) materials as a sensitive sensor for acetone gas. The calculation results indicate the unfavorable detection property for the pristine 2D-InP surface upon acetone with an unsatisfied gas response (12.

Miniaturized spectrometers based on graded photonic crystal films.

Miniaturized spectrometers have become increasingly important in modern analytical and diagnostic applications due to their compact size, portability, and versatility. Despite the surge in innovative designs for miniaturized spectrometers, significant challenges persist, particularly concerning manufacturing cost and efficiency when devices become smaller. Here we introduce an ultracompact spectrometer design that is both cost-effective and highly efficient.

Engineering Topological and Chemical Disorder in Pd Sites for Record-Breaking Formic Acid Electrocatalytic Oxidation.

Designing palladium-based formic acid oxidation reaction (FAOR) catalysts to achieve significant breakthroughs in catalytic activity, pathway selectivity, and toxicity resistance is both urgent and challenging. Here, these challenges are addressed by pioneering a novel catalyst design that incorporates both topological and chemical disorder, developing a new class of PdCuLaYMnW high-entropy amorphous alloys with a porous network (Net-Pd-HEAA) as a highly active, selective, and stable FAOR electrocatalyst. This novel Net-Pd-HEAA demonstrates record-breaking FAOR performance, achieving the mass and specific activities of 5.

Preoperative D-dimer and outcomes in obstructive hypertrophic cardiomyopathy after myectomy.

Background: The prognostic significance of D-dimer in patients with hypertrophic cardiomyopathy undergoing septal myectomy has not been well established.

Methods: We retrospectively analyzed D-dimer levels in 728 patients who underwent septal myectomy at our hospital between 2009 and 2018. Baseline D-dimer levels were categorized into tertiles (<0.

Open-loop narrowband magnetic particle imaging based on mixed-frequency harmonic magnetization response.

Introduction: Magnetic particle imaging (MPI), a radiation-free, dynamic, and targeted imaging technique, has gained significant traction in both research and clinical settings worldwide. Signal-to-noise ratio (SNR) is a crucial factor influencing MPI image quality and detection sensitivity, and it is affected by ambient noise, system thermal noise, and the magnetization response of superparamagnetic nanoparticles. Therefore to address the high amplitude system and inherent thermal noise present in conventional MPI systems is essential to improve detection sensitivity and imaging resolution.

Warm growing season activates microbial nutrient cycling to promote fertilizer nitrogen uptake by maize.

The influence of nitrogen (N) inputs on soil microbial communities and N uptake by plants is well-documented. Seasonal variations further impact these microbial communities and their nutrient-cycling functions, particularly within multiple cropping systems. Nevertheless, the combined effects of N fertilization and growing seasons on soil microbial communities and plant N uptake remain ambiguous, thereby constraining our comprehension of the optimal growing season for maximizing crop production.

Cu surface plasmon resonance promoted charge transfer in S-scheme system enhanced visible light photocatalytic hydrogen evolution.

Reasonably constructing nanocomposite photocatalysts with fast charge transfer and broad solar response capabilities is significant for efficiently converting solar energy into chemical energy. Cu modifies P25/CeO heterojunctions prepared by photodeposition (P25 is commercial TiO). The local surface plasmon resonance (LSPR) effect caused by Cu nanoparticles broadens the spectral response range and generates significant photothermal effects.

CN/Se-CNTs as Advanced Metal-Free Catalysts for the Photoassisted Electrocatalytic Oxygen Evolution Reaction.

Photoassisted electrocatalysis is a frontier direction of electrocatalysis for promoting energy conversion. In this work, a metal-free CN/Se-CNTs is reported as a novel catalyst for photoassisted electrocatalytic oxygen evolution reaction (OER). CN has an appropriate bandgap, high specific surface area, and long-term stability.