Publications by authors named "Hanzhong Wang"

Purpose: Prolonged scanning durations are one of the primary barriers to the widespread clinical adoption of dynamic Positron Emission Tomography (PET). In this paper, we developed a deep learning algorithm that capable of predicting dynamic images from dual-time-window protocols, thereby shortening the scanning time.

Methods: This study includes 70 patients (mean age ± standard deviation, 53.

View Article and Find Full Text PDF

Purpose: Recent development in positron emission tomography (PET) dramatically increased the effective sensitivity by increasing the geometric coverage leading to total-body PET imaging. This encouraging breakthrough brings the hope of ultra-low dose PET imaging equivalent to transatlantic flight with the assistance of deep learning (DL)-based methods. However, conventional DL approaches face limitations in addressing the heterogeneous domain of PET imaging.

View Article and Find Full Text PDF

Germin-like proteins (GLPs) play important roles in the regulation of various plant development processes, such as seed vigor, root and leaf development and disease resistance, while the roles of on agronomic traits are rarely studied in . Here, we identified family genes in rapeseed and analyzed their potential functions. There are 77 family genes () in the Zhongshuang11 rapeseed reference genome, divided into a, b, c, d, e, f six subfamilies.

View Article and Find Full Text PDF
Article Synopsis
  • Reducing radiation dose in PET scans is crucial due to cancer risks, but low-dose scans lead to high image noise that affects quality and diagnosis.
  • Recent deep learning advancements show promise for enhancing image quality, but traditional neural networks struggle with varying noise levels unless trained specifically for each level.
  • The Unified Noise-aware Network (UNN) proposes a solution by integrating multiple sub-networks to effectively denoise PET images across different noise levels, demonstrating superior performance in tests compared to single-noise-level networks.
View Article and Find Full Text PDF

Rapeseed ( L.) seedlings are rich in vitamin C (Vc), which is beneficial for humans. Understanding the genetic variance in Vc content has practical significance for the breeding of "oil-vegetable dual-purpose" rapeseed.

View Article and Find Full Text PDF

Purpose: Generating polar map (PM) from [Ga]Ga-DOTA-FAPI-04 PET images is challenging and inaccurate using existing automatic methods that rely on the myocardial anatomical integrity in PET images. This study aims to enhance the accuracy of PM generated from [Ga]Ga-DOTA-FAPI-04 PET images and explore the potential value of PM in detecting reactive fibrosis after myocardial infarction and assessing its relationship with cardiac function.

Methods: We proposed a deep-learning-based method that fuses multi-modality images to compensate for the cardiac structural information lost in [Ga]Ga-DOTA-FAPI-04 PET images and accurately generated PMs.

View Article and Find Full Text PDF

Rapeseed () has the ability of selenium (Se) enrichment. Identification of selenides in Se-rich rapeseed products will promote the development and utilization of high value. By optimizing the Se species extraction process (protease type, extraction reagent, enzyme sample ratio, extraction time, etc.

View Article and Find Full Text PDF

Background Translocator protein (TSPO) PET has been used to visualize microglial activation in neuroinflammation and is a potential imaging tool for detecting autoimmune encephalitis (AIE). Purpose To compare the detection rate between TSPO radioligand fluorine 18 (F) DPA-714 PET and conventional MRI and assess the relationship between F-DPA-714 uptake and clinical features in participants with AIE. Materials and Methods Healthy volunteers and patients with AIE were enrolled in this prospective study between December 2021 and April 2023.

View Article and Find Full Text PDF

We detected the major QTL- qSR.A07, which regulated stem strength and was fine-mapped to 490 kb. BnaA07G0302800ZS and BnaA07G0305700ZS as the candidate functional genes were identified at qSR.

View Article and Find Full Text PDF

As plant-specific transcription factors, the TIFY family genes are involved in the responses to a series of biotic and abiotic stresses and the regulation of the development of multiple organs. To explore the potential roles of the TIFY gene family in shoot branching, which can shape plant architecture and finally determine seed yield, we conducted comprehensive genome-wide analyses of the TIFY gene family in . Here, HMMER search and BLASTp were used to identify the TIFY members.

View Article and Find Full Text PDF

Selenium is an essential micronutrient that plays a crucial role in maintaining human health. Selenium deficiency is seriously associated with various diseases such as Keshan disease, Kashin-Beck disease, cataracts, and others. Conversely, selenium supplementation has been found to have multiple effects, including antioxidant, anti-inflammatory, and anticancer functions.

View Article and Find Full Text PDF

Background: Rapeseed (Brassica napus L.) is an essential source of edible oil and livestock feed, as well as a promising source of biofuel. Breeding crops with an ideal root system architecture (RSA) for high phosphorus use efficiency (PUE) is an effective way to reduce the use of phosphate fertilizers.

View Article and Find Full Text PDF

LGP2 is a RIG-I-like receptor (RLR) known to bind and recognize the intermediate double-stranded RNA (dsRNA) during virus infection and to induce type-I interferon (IFN)-related antiviral innate immune responses. Here, we find that LGP2 inhibits Zika virus (ZIKV) and tick-borne encephalitis virus (TBEV) replication independent of IFN induction. Co-immunoprecipitation (Co-IP) and confocal immunofluorescence data suggest that LGP2 likely colocalizes with the replication complex (RC) of ZIKV by interacting with viral RNA-dependent RNA polymerase (RdRP) NS5.

View Article and Find Full Text PDF

Root system architecture (RSA) is the primary predictor of nutrient intake and significantly influences potassium utilization efficiency (KUE). Uncertainty persists regarding the genetic factors governing root growth in rapeseed. The root transcriptome analysis reveals the genetic basis driving crop root growth.

View Article and Find Full Text PDF

Stem lodging resistance is a serious problem impairing crop yield and quality. ZS11 is an adaptable and stable yielding rapeseed variety with excellent resistance to lodging. However, the mechanism regulating lodging resistance in ZS11 remains unclear.

View Article and Find Full Text PDF

Background Annualized Relapse Rate (ARR) is one of the most important indicators of disease progression in patients with Multiple Sclerosis (MS). However, imaging markers that can effectively predict ARR are currently unavailable. In this study, we developed a deep learning-based method for the automated extraction of radiomics features from Positron Emission Computed Tomography (PET) and Magnetic Resonance (MR) images to predict ARR in patients with MS.

View Article and Find Full Text PDF

Heterosis refers to the better performance of cross progeny compared with inbred parents, and its utilization contributes greatly to agricultural production. Several hypotheses have been proposed to explain heterosis mainly including dominance, over-dominance (or pseudo-overdominance) and epistasis. However, systematic dissection and verification of these hypotheses are rarely documented.

View Article and Find Full Text PDF

Upon recognizing danger signals produced by virally infected neurons, macrophages in the central nervous system (CNS) secrete multiple inflammatory cytokines to accelerate neuron apoptosis. The understanding is limited about which key effectors regulate macrophage-neuron crosstalk upon infection. We have used neurotropic-virus-infected murine models to identify that vascular endothelial growth factor receptor 3 (VEGFR-3) is upregulated in the CNS macrophages and that virally infected neurons secrete the ligand VEGF-C.

View Article and Find Full Text PDF

Drought stress poses a serious threat to global agricultural productivity and food security. Plant resistance to drought is typically accompanied by a growth deficit and yield penalty. Herein, we report a previously uncharacterized, dicotyledon-specific gene, Stress and Growth Interconnector (SGI), that promotes growth during drought in the oil crop rapeseed (Brassica napus) and the model plant Arabidopsis (Arabidopsis thaliana).

View Article and Find Full Text PDF

Zika virus (ZIKV) infections are typically asymptomatic but cause severe neurological complications (e.g. Guillain-Barré syndrome in adults, and microcephaly in newborns).

View Article and Find Full Text PDF

Branch architecture is an important factor influencing rapeseed planting density, mechanized harvest, and yield. However, its related genes and regulatory mechanisms remain largely unknown. In this study, branch angle (BA) and branch dispersion degree (BD) were used to evaluate branch architecture.

View Article and Find Full Text PDF

Oilseed rape is one of the world's largest oil and industrial crops, providing humans with various products, such as vegetable oil and biofuel. Ovules are the direct precursors of seeds, and ovule number per ovary (ONPO) largely determines seed number per fruit that affects both yield and fitness of seed crops. The ONPO shows wide variation in oilseed rape, whereas the underlying genes and mechanisms are poorly known.

View Article and Find Full Text PDF