Publications by authors named "Hanzhe Wang"
Article Synopsis
- Type 2 diabetes mellitus (T2DM) worsens bone loss in periodontitis, but the underlying mechanism affecting bone regeneration is not fully understood.
- Abnormal exosomes from the impaired liver in T2DM are found to increase in the periodontal area, causing destructive cell death (pyroptosis) in periodontal ligament cells.
- The study identifies fatty acid synthase (Fasn) in these exosomes as a key player in disrupting cell function and promoting bone loss, suggesting that targeting liver Fasn could help mitigate these effects.
