Hypoxia-reprogramed megamitochondrion contacts and engulfs lysosome to mediate mitochondrial self-digestion.

Mitochondria are the key organelles for sensing oxygen, which is consumed by oxidative phosphorylation to generate ATP. Lysosomes contain hydrolytic enzymes that degrade misfolded proteins and damaged organelles to maintain cellular homeostasis. Mitochondria physically and functionally interact with lysosomes to regulate cellular metabolism.

Application of Big Data Technology and Visual Neural Network in Emotional Expression Analysis of Oil Painting Theme Creation in Public Environment.

With the progress of science and technology and the arrival of the big data era, people increasingly rely on computers to deal with daily life and related affairs. In recent years, machine learning has become more and more popular and has achieved good results in some fields, which also makes machine learning widely used. Among them, visual neural network technology can more intelligently analyze the emotional expression of oil painting, which is one of the current research hotspots, involving machine vision, pattern recognition, image processing, artificial intelligence, and other fields.

LIMP2 gene, evolutionarily conserved regulation by TFE3, relieves lysosomal stress induced by cholesterol.

Aim: Excess cholesterol deposition in lysosomes may result in lysosomal stress and dysfunction. Here, we focus on the role of lysosome membrane protein 2 (LIMP2) in relieving the lysosomal stress caused by excess cholesterol and the mechanism that regulate its expression.

Material And Methods: Cholesterol enrichment in lamprey liver tissue was evaluated by RNA transcriptome data analysis, RT-qPCR, H&E, and Oil Red O staining.

Bioinformatis analysis reveals possible molecular mechanism of PXR on regulating ulcerative colitis.

Inflammatory bowel disease (IBD) is a chronic, recurrent inflammatory disease of the gastrointestinal (GI) tract. Ulcerative colitis (UC) is a type of IBD. Pregnane X Receptor (PXR) is a member of the nuclear receptor superfamily.