Publications by authors named "Hanyin Hong"
J Biochem Mol Toxicol
October 2023
Article Synopsis
- The study focuses on lncRNA PTOV1-AS1's role in hepatocellular carcinoma (HCC) and its contribution to resistance against the cancer drug sorafenib.
- Higher levels of PTOV1-AS1 were found in HCC tissues compared to normal tissues, and its expression correlates with patient survival rates.
- Knocking down PTOV1-AS1 reduced cell growth and invasion in sorafenib-resistant HCC cells by interacting with miR-505, suggesting that targeting PTOV1-AS1 could improve treatment outcomes.
Article Synopsis
- The study investigates the effectiveness and safety of combining Toripalimab and Anlotinib for treating unresectable hepatocellular carcinoma (uHCC) after delivering Stereotactic Body Radiation Therapy (SBRT) to expose tumor antigens.
- A total of 20 patients with intermediate to advanced uHCC participated, and results indicated a median progression-free survival (PFS) of 7.4 months.
- Notable findings included an overall survival rate of 61.1% at 18 months and 50.9% at 24 months, with treatment-related adverse events occurring in 70% of participants, highlighting the therapy's potential and the need for further research.
