Predicting post-operative complications in obese cardiac surgery patients is complicated due to long-term metabolic issues linked to obesity, particularly involving branched-chain amino acids (BCAAs).
The study examines whether changes in BCAA metabolism can be used as predictors for adverse outcomes in these patients, analyzing blood and tissue samples from various BMI categories.
Findings reveal that while intramyocellular BCAAs rise with BMI, there's decreased activity of BCAA catabolic enzymes in the adipose tissue of severely obese individuals, indicating a connection between BCAA metabolism, metabolic dysfunction, and recovery after surgery.