Altered Neuronal Activity Patterns of the Prefrontal Cortex in Alzheimer's Disease After Transcranial Alternating Current Stimulation: A Resting-State fMRI Study.

Background: Transcranial alternating current stimulation (tACS) could improve cognition in patients with Alzheimer's disease (AD). However, the effects of tACS on brain activity remain unclear.

Objective: The purpose is to investigate the change in regional neuronal activity after tACS in AD patients employing resting-state functional magnetic resonance imaging (rs-fMRI).

FedETC: Encrypted traffic classification based on federated learning.

The current popular traffic classification methods based on feature engineering and machine learning are difficult to obtain suitable traffic feature sets for multiple traffic classification tasks. Besides, data privacy policies prohibit network operators from collecting and sharing traffic data that might compromise user privacy. To address these challenges, we propose FedETC, a federated learning framework that allows multiple participants to learn global traffic classifiers, while keeping locally encrypted traffic invisible to other participants.

Reprogramming mitochondrial metabolism of macrophages by miRNA-released microporous coatings to prevent peri-implantitis.

Although various new biomaterials have enriched the methods for peri-implant inflammation treatment, their efficacy is still debated, and secondary operations on the implant area have also caused pain for patients. Recently, strategies that regulate macrophage polarization to prevent or even treat peri-implantitis have attracted increasing attention. Here, we prepared a laser-drilled and covered with metal organic framework-miR-27a agomir nanomembrane (L-MOF-agomir) implant, which could load and sustain the release of miR-27a agomir.

Low-loss microwave photonic switching for satellite communication.

For traditional switching architecture, packet switching performs fine granularity data packet forwarding, but its digital signal processing (DSP) has high power consumption (PC). All-optical switching provides rapid exchange of wavelength resources, which has coarse granularity. In scenarios where the PC is limited, such as broadband satcom, a switching architecture with lower PC and finer granularity than optical switching would be useful.

Application of Immediate Implant Placement Techniques in Peri-implantitis Modeling.

Objectives: To explore the use of immediate implant placement technique in peri-implantitis modeling, shorten the modeling period, and obtain similar effects.

Materials And Methods: Eighty rats were divided into 4 groups: immediate placement (IP), delayed placement (DP), IP-ligation (IP-L) and DP-ligation (DP-L). In the DP and DP-L groups, implants were placed 4 weeks after tooth extraction.

Broadband dual-channel channelizer based on a microwave photonic power tunable image rejection down-conversion.

Radiofrequency (RF) channelization has potential high frequency and wideband advantages in frequency-domain channel segmentation and down-conversion reception. In this paper, we propose a compact dual-channel channelizer that can process high-frequency wideband signals. It uses double-polarization double-sideband electro-optic modulation and Hartley structure photoelectric conversion to realize down-conversion channelization of the high-frequency wideband signal.

MicroRNA sequence and function analysis in peri-implantitis and periodontitis: An animal study.

Objective: To compare miRNA expression levels and predict relevant target genes and signaling pathways in peri-implantitis and periodontitis.

Background: There are many differences between periodontitis and peri-implantitis. An understanding of the similarities and differences in the transcriptional patterns of these diseases, as well as the molecular mechanisms, is beneficial for the development of management strategies.

Salivary microbiome in patients undergoing hemodialysis and its associations with the duration of the dialysis.

Background: Chronic kidney disease (CKD) patients, especially those with end stage renal disease (ESRD) undergoing hemodialysis (HD), exhibit high prevalence of periodontitis. This cross-sectional study aimed to investigate the periodontal status of HD patients and its relationship with salivary microbiome.

Methods: One hundred eight HD patients and one hundred healthy control individuals were recruited.

The role of USP34 in the fixation of titanium implants in murine models.

Ubiquitin-specific protease 34 (USP34), a member of the ubiquitin-specific protease family, regulates osteogenic differentiation of bone marrow mesenchymal stem cells via bone morphogenetic protein signaling. This study aimed to investigate the role of USP34 in fixation of titanium implants in mouse models. Eight-week-old Usp34-knockout (Prx1-Cre;Usp34 ) mice and their Usp34 wild-type (Usp34 ) control littermates were used.

Ubiquitin-Specific Protease 34 Inhibits Osteoclast Differentiation by Regulating NF-κB Signaling.

The ubiquitination and deubiquitination enzymes ensure the stability and proper function of most cellular proteins. Disturbance of either enzyme compromises tissue homeostasis. We recently have identified that the ubiquitin-specific protease 34 (USP34) contributes to bone formation by promoting osteogenic differentiation of mesenchymal stem cells.

Growth differentiation factor 11 impairs titanium implant healing in the femur and leads to mandibular bone loss.

Background: Growth differentiation factor 11 (GDF11), a secreted member of the transforming growth factor-β superfamily, has recently been suggested as an anti-aging factor that declines with age in the bloodstream, and restoration of the youthful level by administration of its recombinant protein could reverse age-related dysfunctions. However, its effects on titanium implant osseointegration and mandibular bone during aging remain unknown.

Methods: Two-month-old and 18-month-old C57BL male mice were given daily intraperitoneal injections of recombinant GDF11 (rGDF11) or vehicle for 6 weeks.