[Mechanism of immune tolerance induced by soluble myelin oligodendrocyte glycoprotein in mice with experimental autoimmune encephalomyelitis].

Objective To explore the mechanism of immune tolerance induced by soluble MOG (MOG) peptide in mice with experimental autoimmune encephalomyelitis (EAE). Methods EAE mice were randomly divided into three groups, MOG, OVA and control groups, which were injected intraperitoneally with MOG, OVA peptide and PBS, respectively, from day 6 to day 16 after EAE induction. Lymphocytes in the spleen and CNS were enumerated and their phenotypes and function were analyzed by flow cytometry to explore the role of T cell migration in MOG-induced EAE tolerance.

Antigen-oriented T cell migration contributes to myelin peptide induced-EAE and immune tolerance.

Treatment with soluble myelin peptide can efficiently and specifically induce tolerance to demyelination autoimmune diseases including multiple sclerosis, however the mechanism underlying this therapeutic effect remains to be elucidated. In actively induced mouse model of experimental autoimmune encephalomyelitis (EAE) we analyzed T cell and innate immune cell responses in the central nervous system (CNS) and spleen after intraperitoneal (i.p.