Comprehensive analysis of EphA2 in pan-cancer: A prognostic biomarker associated with cancer immunity.

Background: Several studies have reported a significant relationship between Ephrin receptor A2 (EphA2) and malignant progression in numerous cancers. However, there is a lack of comprehensive pan-cancer analysis on the prognostic value, mutation status, methylation landscape, and potential immunological function of EphA2.

Method: Using The Cancer Genome Atlas, Genotype Tissue Expression Database and GEO data, we analysed the differences in EphA2 expression between normal and tumour tissues and the effects of EphA2 on the prognosis of different tumours.

Achievement of efficient thermally activated delayed fluorescence materials based on 1,8-naphthalimide derivatives exhibiting piezochromic and thermochromic luminescence.

In this study, we developed a D-A type imide derivative based on 1,8-naphthalimide, NI-mPCz, which exhibited outstanding thermally activated delayed fluorescence (TADF) properties. Additionally, it demonstrates characteristics of piezochromic and thermochromic luminescence. The thermochromic luminescence observed is attributed to crystalline transformations occurring during the heating process, as evidenced by differential scanning calorimetry (DSC) and microscopic examinations.