Publications by authors named "Hanxiang Ouyang"
V9302-loaded copper-polyphenol hydrogel for enhancing the anti-tumor effect of disulfiram.
J Colloid Interface Sci
January 2025
Article Synopsis
- Disulfiram (DSF) is a drug that shows potential for treating tumors but can cause systemic toxicity when combined with copper (Cu) in non-tumor tissues due to a harmful compound, CuET.
- A new treatment method combines DSF with a hydrogel that releases copper and a drug (V9302) that limits glutamine uptake to enhance the effectiveness of the therapy.
- Experiments on cells and animals demonstrate that this combination can effectively kill tumor cells and reduce tumor growth without harming major organs.
Hepatocellular injury, a pivotal contributor to liver diseases, particularly hepatitis, lacks effective pharmacological treatments. Interleukin-22 (IL-22), crucial for liver cell survival, shows potential in treating liver diseases by regulating repair and regeneration through signal transducer and activator of transcription 3 (STAT3) activation. However, the short half-life and off-target effects limit its clinical applications.
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