Radial tears in the anterior third of the lateral meniscus are frequently combined with horizontal tears.

Introduction: Radial tears of the lateral meniscus are often located in the junction of the middle and posterior third or posterior tibial attachment. However, we observed that a few cases of radial tears occurred in the anterior third of the lateral meniscus, and in many cases, they were accompanied by horizontal tears.

Hypothesis: Radial tears are more frequently accompanied by horizontal tears in the anterior third of the lateral meniscus than in other regions.

Progression of Allograft Extrusion in Both the Coronal and Sagittal Planes at Midterm Follow-up After Medial Meniscal Allograft Transplant.

Background: Although many studies have examined allograft extrusion after medial meniscal allograft transplant (MMAT), it is unclear whether allograft extrusion progresses at midterm follow-up.

Hypothesis: After MMAT, allograft extrusion would not progress during the midterm follow-up period.

Study Design: Case series; Level of evidence, 4.

Clinicoradiologic Outcomes of Medial Open-Wedge High-Tibial Osteotomy Are Equivalent in Bone-on-Bone and Non-Bone-on-Bone Medial Osteoarthritis.

Purpose: (1) To investigate whether patients with bone-on-bone (BOB) medial OA (Ahlback grade 2) had comparable clinical improvement to those with non-BOB arthritis with remaining joint space (Ahlback grades 0/1) after medial open-wedge high tibial osteotomy (MOWHTO); (2) to determine whether the radiological results differ between these 2 groups from 1 month postoperatively to last follow-up ≥2 years later.

Methods: Data of 132 knees (40 males and 92 females) who underwent MOWHTO were retrospectively reviewed. Preoperative standing anteroposterior radiographs were evaluated according to the Ahlback classification.

Successful Limb Salvage Using Bone Transport for Complete Loss of Distal Tibia and Talus: A Case Report.

Complex comminuted fractures involving the distal tibia, ankle joint, and talus are often accompanied by bone loss and are highly prone to complications such as soft tissue infection, fixation failure, and posttraumatic arthrosis, with joint reconstruction being difficult in cases with severe joint destruction or bone loss. In this case, bone transport and fusion procedures were performed to treat a patient with an open fracture involving total talar dislocation, talar bone loss, and distal tibial bone loss. Just as in this case, where the surrounding soft tissues remain healthy, limb salvage via segmental bone transport may be a reasonable option in fractures with massive bone loss that include joints.

Synovial fluid levels of TWEAK and matrix metalloproteinase 1 in patients with osteoarthritis, and associations with disease severity.

Purpose: This study assessed the levels of soluble tumor necrosis factor-like weak inducer of apoptosis (TWEAK) and matrix metalloproteinase 1 (MMP-1) in the synovial fluid from osteoarthritic knees to determine their role as well as the relationship between these levels and the severity of osteoarthritis (OA).

Methods: Synovial fluid was obtained from 44 knees of 40 patients. The Kellgren-Lawrence (KL) grade was measured using radiograph.

Neuroprotective effects of 2-cyclopropylimino-3-methyl-1,3-thiazoline hydrochloride against oxidative stress.

Oxidative stress, glutamate excitotoxicity, and inflammation are the important pathological mechanisms in neurodegenerative diseases. Recently, we reported that 2-cyclopropylimino-3-methyl-1,3-thiazoline hydrochloride protects rat glial cells against glutamate-induced excitotoxicity. In this study, we report the effects of 2-cyclopropylimino-3-methyl-1,3-thiazoline hydrochloride on primary cultured cortical astrocytes after exposure to hydrogen peroxide (H₂O₂).

Suppression of lipopolysaccharide-induced microglial activation by a benzothiazole derivative.

We previously reported that KHG21834, a benzothiazole derivative, attenuates the beta-amyloid (Abeta)-induced degeneration of both cortical and mesencephalic neurons in vitro. Central nervous system inflammation mediated by activated microglia is a key event in the development of neurodegenerative disease. In this study, we show that KHG21834 suppresses inflammation-mediated cytokine upregulation.