Publications by authors named "Hantoushzadeh S"

Background: Hyperglycemia in pregnancy is believed to be associated with negative pregnancy outcomes. However, establishing a causal connection between diabetes mellitus (DM) and adverse pregnancy results is challenging due to the limitations inherent in traditional observational studies.

Methods: Our study used a two-sample Mendelian randomization (MR) technique to examine the possible influence of pregestational diabetes mellitus (PGDM) on adverse pregnancy outcomes.

View Article and Find Full Text PDF

Objective: Menopause is a significant period in a woman's life that can be natural or surgical. We aimed to assess the association between the type of menopause and sleep quality, especially in elderly women.

Method: This was a cross-sectional study using data from the first phase of the Ardakan Cohort Study on Ageing (ACSA) of 50 and above years of menopausal women, distributed into two groups of natural and surgical menopause.

View Article and Find Full Text PDF

Background: COVID-19 infection during pregnancy could be associated with placental histopathological changes such as vascular diseases and malperfusion. There are studies showing that mRNA vaccines are not associated with significant placental pathological changes. Our objective was to evaluate the placental histopathology in pregnant women who received Sinopharm, an inactivated virus vaccine, during pregnancy.

View Article and Find Full Text PDF

Contrary to the evidence supporting the role for insulin in stimulating uterine contraction, only a limited number of studies have highlighted the inhibitory effect of insulin on myometrial contractions in human and rodent. A hypothetical narrative review of the current literature was conducted, revealing the current literature and shows the potential inhibitory effects of insulin on myometrial contractility. These inhibitory mechanisms include activation of adenylyl cyclase signaling pathways, an increase in cAMP production, a decrease in Ca influx and cytosolic Ca, hyperpolarization of the cell membrane, and stimulation of NO synthesis.

View Article and Find Full Text PDF

Background: Gestational Diabetes Mellitus (GDM) is a common complication during pregnancy. Late diagnosis can have significant implications for both the mother and the fetus. This research aims to create an early prediction model for GDM in the first trimester of pregnancy.

View Article and Find Full Text PDF

Background: Early identification of gestational diabetes mellitus is essential for improving maternal and neonatal outcomes. While risk factors such as advanced maternal age, elevated pre-pregnancy body mass index, multiparity, and a history of gestational diabetes have been recognized, the role of serum biomarkers remains uncertain. This study explores the predictive value of early-pregnancy laboratory findings in conjunction with maternal demographic and clinical characteristics for gestational diabetes mellitus.

View Article and Find Full Text PDF

Myo-inositol may be efficient to improve sperm parameters to increase the chance of fertility. Although, the data are controversial. This study aimed to assess the impact of Myo-inositol supplements on semen quality and in vitro fertilization (IVF) outcomes.

View Article and Find Full Text PDF

Background: The Iranian National Health Service (NHS) suggested that gynecologists face a higher risk of medicolegal claims, with a significant number of claims being related to delivery events. This study aimed to investigate the factors associated with delivery related claims.

Method: In this cross-sectional study, we conducted an analysis of medico-legal documents which related to complications during delivery events and presented to Iranian Medical Legal Organization spanning from March 2018 to February 2020.

View Article and Find Full Text PDF
Article Synopsis
  • - The study investigates the relationship between maternal fasting blood sugar (FBS), body mass index (BMI), and age as predictors for gestational diabetes mellitus (GDM) in pregnant women, using data from 4007 Iranian women.
  • - Results show that FBS has a strong correlation with GDM, particularly when considering a cut-off point of 85.95 mg/dL, which produced a sensitivity of 81% and specificity of 71%.
  • - The findings emphasize the importance of maternal weight and BMI in predicting GDM and highlight the need for further research to better standardize FBS cut-off points while accounting for age and BMI.
View Article and Find Full Text PDF
Article Synopsis
  • Gestational diabetes mellitus is common and affects maternal and neonatal health, making it important to find reliable biomarkers for prediction and diagnosis, particularly in patients with intrahepatic cholestasis of pregnancy.* -
  • A systematic search and meta-analysis of 15 studies revealed higher serum total bile acid levels in women with gestational diabetes compared to controls, especially when levels were measured earlier in pregnancy before diagnosis.* -
  • The analysis showed no significant difference in total bile acid levels after gestational diabetes was diagnosed, indicating that earlier measurements might be more predictive of the condition.*
View Article and Find Full Text PDF

Objective: To compare residual myometrial thickness (RMT) and cesarean scar defect (CSD) development after cesarean section using double-layer locked and unlocked closure techniques.

Materials And Methods: We conducted a randomized double-blinded trial comparing double-layer locked and unlocked uterine closure techniques following cesarean section in primiparous women. The locked technique involved continuous suturing of the full myometrial thickness in the first layer, followed by back-and-forth needle maneuvering on both sides of the incision for the second layer.

View Article and Find Full Text PDF
Article Synopsis
  • The systematic review and meta-analysis evaluated the effectiveness of letrozole, both alone and with methotrexate, in treating ectopic pregnancy, using strict PRISMA guidelines for reporting.
  • After examining 129 studies, 7 were included in the final analysis, indicating letrozole may reduce β-HCG levels more effectively than methotrexate after 7 days of treatment.
  • While letrozole showed better or similar results for success rates and certain laboratory findings compared to methotrexate, further randomized clinical trials are needed to solidify these findings.
View Article and Find Full Text PDF

Background: Mistreatment of women during childbirth is a global health challenge. Maternity healthcare providers play a key role in influencing women's birth experience. This study aimed to assess the knowledge, attitudes, and practices of healthcare providers regarding mistreatment of women during labour and childbirth in public hospitals in Tehran, Iran.

View Article and Find Full Text PDF
Article Synopsis
  • Iran has seen a significant rise in cancer cases, creating challenges in oncofertility, which focuses on maintaining fertility post-cancer treatment.
  • A cross-sectional study involving 423 healthcare providers revealed that over 30% had no education on fertility preservation, and more than 20% do not incorporate FP strategies in treatment.
  • The results indicate a critical need for improved training and awareness among healthcare workers regarding fertility preservation options for young cancer patients in Iran.
View Article and Find Full Text PDF

Background: The administration of antenatal corticosteroid is a standard treatment to reduce the rate of perinatal mortality and morbidity; however, there is limited evidence regarding the potential effects of betamethasone on the constriction of the ductus arteriosus (DA).

Objective: This study aimed to investigate the short-term effects of antenatal betamethasone on fetal cardiovascular and circulation status.

Materials And Methods: This quasi-experimental observational (before-after) study was conducted on 32 singleton fetuses.

View Article and Find Full Text PDF

Problem: Achieving pregnancy through in vitro fertilization (IVF) remains a challenge, with less than one-third of women succeeding. There is a pressing need for reliable predictive tools to assess the likelihood of post-IVF pregnancy. While some serum inflammatory biomarkers have been investigated for their predictive potential, substantial knowledge gaps persist.

View Article and Find Full Text PDF
Article Synopsis
  • Digital Polymerase Chain Reaction (dPCR) is a highly efficient method for quantifying DNA and identifying copy number variants, particularly useful in non-invasive prenatal testing for conditions like trisomy 21, 18, and 13.
  • A systematic review analyzed 9 studies to assess dPCR's effectiveness, showing high pooled sensitivity (98%) and specificity (99%) for trisomy 21 when compared to traditional karyotyping.
  • The results indicate dPCR is a promising alternative to next-generation sequencing for prenatal testing, although more research is needed to confirm its effectiveness for trisomies 18 and 13.
View Article and Find Full Text PDF

Background: Mistreatment during childbirth is a growing concern worldwide, especially in developing countries, such as Iran. In response, we launched a comprehensive implementation research (IR) project to reduce mistreatment during childbirth and enhance positive birth experiences in birth facilities. This study identified the challenges of implementing a multi-level intervention to reduce mistreatment of women during childbirth using the Consolidated Framework for Implementation Research (CFIR).

View Article and Find Full Text PDF

Background: Fetal movement monitoring is one of the strategies used to assess the fetus's health. Until now, most studies focused on the decreased fetal movement and neonatal outcome, although this systematic review and meta-analysis is designed to assess the association between increased fetal movements (IFM) with perinatal outcomes.

Method: The electronic databases including PubMed, Scopus, Web of Science, and EMBASE were systematically searched for studies investigating the perinatal outcome of women with increased fetal movements from inception to July 2023.

View Article and Find Full Text PDF

Background: A birth companion is a powerful mechanism for preventing mistreatment during childbirth and is a key component of respectful maternity care (RMC). Despite a growing body of evidence supporting the benefits of birth companions in enhancing the quality of care and birth experience, the successful implementation of this practice continues to be a challenge, particularly in developing countries. Our aim was to investigate the acceptability, adoption, appropriateness, feasibility, and fidelity of implementation strategies for birth companions to mitigate the mistreatment of women during childbirth in Tehran.

View Article and Find Full Text PDF

Purpose: Diagnosing the placenta accreta spectrum is crucial to prevent morbidities and mortalities among women with the suspicion of this pathology. We aim to evaluate novel ultrasonography markers for these patients in diagnosing and predicting prognosis.

Methods: This cross-sectional study was performed in a referral academic hospital.

View Article and Find Full Text PDF

Background: Pre-eclampsia (PE) is a multiorgan disorder that affects 2-5% of all pregnant women. Present recommendations for when to start aspirin in high-risk women are after 11 wk of gestation.

Objective: We present a protocol to investigate the effectiveness of aspirin use from early pregnancy, which is a randomized controlled trial to assess whether prescribed low-dose aspirin from early pregnancy reduces the prevalence of early and late-onset PE.

View Article and Find Full Text PDF