Ultrastructural and electrophysiological changes in the olfactory epithelium following exposure to organic solvents.

The present study describes some effects on frog olfactory mucosa following acute exposure to styrene and toluene, two organic solvents. The olfactory summed receptor potential (EOG) was recorded in order to monitor the functional effect. The olfactory epithelium was examined with transmission electron microscopy, using both thin section and freeze-fracture technique.

A thin-section and freeze-fracture study of the pulp blood vessels in feline and human teeth.

The fine structure of blood vessels with a diameter of less than 50 micrometers, i.e. small arterioles, capillaries and postcapillary venules were studied.

Plasma lipoproteins and lipolytic enzyme activities during endurance training in sedentary men: changes in high-density lipoprotein subfractions and composition.

Eighteen healthy sedentary males took part in supervised bicycle training for 50 minutes three to five times a week. Twelve subjects (group A) trained for 6 weeks at heavy intensity, and six subjects (group B) trained for 12 weeks at moderate intensity. Maximal oxygen uptake increased by about 20% (P less than 0.

Influence of nutritional state on lipoprotein lipase activities in the hypothyroid rat.

We have investigated the effects of nutritional state on the lipoprotein lipase activities of the experimentally hypothyroid rat. Both short-term effects (i.e.

Experimental hyperthyroidism in man: effects on plasma lipoproteins, lipoprotein lipase and hepatic lipase.

We have studied the effects of triiodothyronine administration (20-40 micrograms three times daily over one week) in six healthy young men, on the activities of lipoprotein lipase and hepatic lipase and on plasma lipoprotein concentrations. Hepatic lipase activity in post-heparin plasma rose by 46 +/- 25% (p less than 0.025), whereas the activity of lipoprotein lipase did not change significantly.

Relations between thyroid function, hepatic and lipoprotein lipase activities, and plasma lipoprotein concentrations.

Lipoprotein concentrations and activities of lipoprotein lipase (LPL) and hepatic lipase (HL) were measured in 70 subjects with thyroid function ranging from overt hypothyroidism over subclinical hypothyroidism and euthyroidism to hyperthyroidism. In parallel with serum T3 (S-T3) concentrations increasing from low in hypothyroidism to high in hyperthyroidism there were gradually higher HL activities over the full spectrum of thyroid function, accompanied by decreasing levels of total and low density lipoprotein (LDL) cholesterol. High density lipoprotein (HDL) cholesterol was lower (P less than 0.

Bidirectional axonal transport of thallium in frog sciatic nerve.

Bidirectional axonal transport of radioactivity was demonstrated in frog sciatic nerve in vitro and in vivo after local application of the thallium isotope 204Tl+ to the nerve. The transport rate was similar in both directions and about 30 min/day at 18 degrees C. The transport was depressed by 2,4-DNP, low-temperature and vinblastine.

Transcutaneous electrical nerve stimulation (TENS) as compared to placebo TENS for the relief of acute oro-facial pain.

The present paper describes the effect of high frequency, low frequency and placebo TENS on acute oro-facial pain in 62 patients, attending to an emergency clinic for dental surgery; they had all suffered pain for 1-4 days. The patients were randomly assigned to one of three groups receiving either high frequency (100 Hz), low frequency (2 Hz) or placebo TENS. In the two groups receiving TENS (42 patients) 16 patients reported a reduction in pain intensity exceeding 50%; out of these 16 patients, 4 patients reported complete relief of pain.

Acute effects of ethanol and its metabolites on plasma lipids and lipoprotein lipase activity.

The effects of ethanol, acetaldehyde, acetate and lactate on lipoprotein lipase (LPL) activity and regulation have been investigated. None of the substances had any direct effect on the enzyme or enzyme-substrate complex. Ethanol and acetate interfered with LPL regulation studied in vitro using rat adipose tissue.

Effects of conditioning vibratory stimulation on pain threshold of the human tooth.

The effect of mechanical vibratory stimulation on the human tooth pain threshold has been studied in 4 healthy naïve subjects. Vibration at 10 and 100 Hz was applied to a maxillary incisor and the electrical pain threshold was measured in an adjacent tooth. During the conditioning stimulation the pain threshold increased 1.

Vibratory stimulation for the relief of pain of dental origin.

The present paper describes the effect of vibratory stimulation on pain of dental origin in 36 patients. The patients were from a clinic for dental surgery and all had suffered pain from pulpal inflammation, apical periodontitis or postoperative pain following extraction of an impacted wisdom tooth for more than 2 days. Vibration at 100 Hz was applied to various points in the facial region or the skull.

Neuroleptic-induced attenuation of brain stimulation reward in rats.

In 30-min free-operant tests, the dopamine receptor blockers pimozide (.125, .25, and .

Concurrent intracranial self-stimulation and amphetamine self-administration in rats.

In a two-lever testing chamber, rats had concurrent access to intravenous amphetamine and brain stimulation reinforcers. Responding for each reinforcer was generally increased above baseline rates taken when only one reinforcer was available. Amphetamine stereotypy was observed, but did not interfere with rapid lever-pressing for brain stimulation.