Publications by authors named "Hansol Yi"

Article Synopsis
  • Bach2 is a transcription repressor that influences humoral immunity by regulating the maturation of effector cells in peripheral B cells in response to TLR agonists.
  • Deficiency of Bach2 leads to increased differentiation of follicular B cells into effector cells, resulting in higher production of interleukin-6 and antibodies, along with changes in lipid metabolism.
  • Bach2 functions by repressing the gene Cd36, and inhibiting CD36 or fatty acid oxidation can prevent the differentiation of naive B cells into active immune cells, highlighting its role as a metabolic checkpoint to maintain B cell quiescence.
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Class-switched IgG autoantibodies but not unswitched IgM autoantibodies play a crucial role in the development of systemic lupus erythematosus (SLE). Bach2 is known to be essential for class switch recombination of Ig genes, but recent genomic and clinical studies have suggested an association of Bach2 deficiency with SLE. This study was undertaken to examine the mechanism by which Bach2 regulates the development of SLE.

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