Publications by authors named "Hansen Tan"
Article Synopsis
- Dilated cardiomyopathy (DCM) is a serious heart disease leading to heart failure, with familial DCM being its major form, often linked to mutations in the LMNA gene.
- In this study, researchers tested 14 potential therapeutic candidates in a cardiac model of LMNA DCM to evaluate their effects on heart function, inflammation, fibrosis, and DNA damage.
- Results showed that several candidates improved cardiac function and survival, with specific candidates like Lamin C and Sun1 demonstrating long-term benefits, while Lamin A treatment raised concerns as it could worsen heart conditions in healthy individuals.
Rationale: Pathogenic variations in the lamin gene () cause familial dilated cardiomyopathy (DCM). insufficiency caused by pathogenic variants is believed to be the basic mechanism underpinning -related DCM.
Objective: To assess whether silencing of cardiac causes DCM and investigate the role of Yin Yang 1 () in suppressing DCM.