Publications by authors named "Hansel Tridatmojo Isa"
Validation of spectrophotometric method to quantify cabotegravir in simulated vaginal fluid and porcine vaginal tissue in ex vivo permeation and retention studies from thermosensitive and mucoadhesive gels.
Spectrochim Acta A Mol Biomol Spectrosc
February 2022
Article Synopsis
- - Cabotegravir (CAB) is an antiretroviral therapy for HIV that faces challenges in oral and injection forms due to low solubility and administration difficulties, making the development of a new delivery system crucial.
- - A vaginal drug delivery system for CAB was created using thermosensitive and mucoadhesive gel formulations, which improve drug distribution and bioavailability within the vaginal mucosa.
- - The study validated a UV-visible spectrophotometry method to accurately quantify CAB in various matrices, confirming the gel preparations maintain uniform drug content and a controlled release over 24 hours, but further methods are needed for in vivo studies.
As an effective anti-HIV drug, cabotegravir (CAB) is currently administered via oral and injection routes, leading to several drawbacks, such as poor oral bioavailability and problems in the injection application process, as well as low drug concentration in vaginal tissue of woman patients. To overcome these issues, for the first time, we formulated CAB into three types of vaginal gels, considering the benefits of vaginal tissue as a delivery route. Thermosensitive gel, mucoadhesive gel, and the combination of these gels were developed as suitable carriers for CAB.
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