Mutat Res Genet Toxicol Environ Mutagen
March 2021
Purpose: Age dependent radiation sensitivity for DNA damage after in vitro blood exposure by computer tomography (CT) was investigated.
Materials And Methods: Radiation biomarkers (dicentrics and gammaH2AX) in blood samples of newborns, children under five years and adults after sham exposure (0 mGy), low-dose (41 mGy) and high-dose (978 mGy) in vitro CT exposure were analyzed.
Results: Significantly higher levels of dicentric induction were found for the single and combined newborns/children group compared to adults, by a factor of 1.
Minimally invasive surgery in infants requires great experience and highly specialised skills. However, in most paediatric surgical departments, the number of patients requiring such surgery is usually small and the personal experience of the surgeon limited. An experimental setting with small animals could improve these training conditions if it adequately simulates the underlying situation and conveys beneficial surgical experiences.
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