The pig as an experimental model for colonic healing study of leakage and ischemia in colonic anastomosis.

Background: The object of this experimental study was to develop a model of anastomotic failure due to primary leakage and ischemia in porcine large bowel anastomosis.

Methods: End-to-end anastomosis was constructed at descending colon in 12 pigs. The pigs were randomly divided into three groups.

Small intestinal submucosa for reinforcement of colonic anastomosis.

Background: Different materials have been evaluated for anastomotic reinforcement to prevent gastrointestinal anastomotic leakage. In this experimental study, small intestinal submucosa (SIS) was tested as a sealing for stapled colonic anastomosis in a porcine model. The aims of this study were to determine the macroscopic and microscopic outcomes and to evaluate the safety and feasibility of applying SIS for anastomotic sealing.

Small intestinal submucosa as a bioscaffold for tissue regeneration in defects of the colonic wall.

Background: Small intestinal submucosa (SIS) has proved considerable regenerative capacity for repair of bowel wall defects at different locations. This study assesses the effectiveness of SIS in the repair of defects at a gastrointestinal location with strong bacterial contamination.

Methods: Fourteen domestic pigs had a 4.