Phospholipase Cbeta1 modulates pain sensitivity, opioid antinociception and opioid tolerance formation.

Phospholipase C (PLC) activity has been implicated in multiple opioid-induced sequelae. The relevance of PLC-linked pathways to opioid actions is isoform-specific. Chronic morphine augments PLCbeta1 signaling while diminishing that of PLCbeta3.