Ventilator-induced heat shock protein 70 and cytokine mRNA expression in a model of lipopolysaccharide-induced lung inflammation.

Objective: To investigate the effect of mechanical ventilation with no PEEP (ZEEP) and 4 cmH(2)O PEEP on heat shock protein 70 (HSP70) and pulmonary inflammatory cytokine expression in a model of lipopolysaccharide (LPS) induced lung inflammation.

Design And Setting: Prospective, randomized, experimental animal study.

Subjects And Interventions: We challenged 42 male Sprague-Dawley rats intratracheally with LPS.

Pharmacokinetics and effects of propofol 6% for short-term sedation in paediatric patients following cardiac surgery.

Aims: This paper describes the pharmacokinetics and effects of propofol in short-term sedated paediatric patients.

Methods: Six mechanically ventilated children aged 1-5 years received a 6 h continuous infusion of propofol 6% at the rate of 2 or 3 mg kg-1 h-1 for sedation following cardiac surgery. A total of seven arterial blood samples was collected at various time points during and after the infusion in each patient.

Mechanical ventilation alters the immune response in children without lung pathology.

Objective: This study was undertaken to examine the hypothesis that mechanical ventilation in association with anesthesia would alter the cytokine profile in infants without preexisting lung pathology.

Design And Setting: Prospective observational study in pediatric intensive care unit in a university hospital.

Patients: Twelve infants who were subjected to an uncomplicated diagnostic cardiac catheterization procedure were studied.