Publications by authors named "Hans Merlin Tsahnang Fofack"
In Vitro and In Silico Studies of the Biological Activities of Some Secondary Metabolites Belonging to Ficus sur Forssk (Moraceae): Towards Optimization of Wighteone Metabolite.
Chem Biodivers
September 2024
Based on ethnomedicinal and chemotaxonomic records of Ficus plants, Ficus sur Forssk was studied in the search for bioactive compounds. Eleven known compounds including mixture α -amyrin acetate and β -amyrin acetate (1 and 2), lupeol (3), 3β-acetoxy-olean-12-en-11-one (4), lupenyl acetate (5), taraxastan-3,20-diol (6), 3'- (3-methylbut-2-enyl) biochanin A (7), derrone (8), quercetin (9), stigmasterol (10), and stigmasterol glycoside (11) were isolated from stem barks of Ficus sur Forssk. Their structures were obtained through analysis of spectroscopic data 1D and 2D NMR), mass spectrometry, and by comparison of these data with the literature.
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- * Molecular docking and simulations indicate that these candidates have a strong binding affinity to DPP4, maintaining stable interactions throughout a 200 ns simulation with observed H-bonding.
- * The findings suggest that these compounds could act as effective DPP4 inhibitors, potentially leading to new treatments for type 2 diabetes.
Virtual screening, MMGBSA, and molecular dynamics approaches for identification of natural products from South African biodiversity as potential pi-class glutathione S-transferase inhibitors.
Heliyon
May 2024
We investigated 1012 molecules from natural products previously isolated from the South African biodiversity (SANCDB, https://sancdb.rubi.ru.
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