Off-label use of clomiphene citrate to treat anabolic androgenic steroid induced hypogonadism upon cessation among men (CloTASH) - A pilot study protocol.

Background: Non-prescribed anabolic androgenic steroid (AAS) use is associated with AAS-induced hypogonadism (ASIH), and metabolic, cardiovascular, and mental health risks. Symptoms of ASIH (fatigue, depression, anxiety, sexual dysfunction) are hard to endure following cessation, but there is no consensus on whether endocrine treatment should be used to treat ASIH. This proof-of-concept study aims to explore safety of off-label clomiphene citrate therapy, whether the treatment will reduce the symptoms of androgen deficiency, and to study changes in health risks after cessation.

Treatment-seeking behavior and cardiovascular morbidity among men with anabolic-androgenic steroid use: A cross-sectional study.

Aims: To determine associations between anabolic-androgenic steroid (AAS) use-related morbidity including cardiovascular disease (CVD) and engagement to health services.

Methods: In this cross-sectional study, 90 males with at least 12 months cumulative current or former use of AAS were included. The participants were divided into a treatment-seeking group (TSG) and a non-treatment seeking group (non-TSG) based on their responses to a self-report web questionnaire.

Health service engagement, side effects and concerns among men with anabolic-androgenic steroid use: a cross-sectional Norwegian study.

Background: Recreational use of anabolic-androgenic steroids (AAS) is a public health concern world-wide associated with a range of physical and psychological side effects. Still, people who use AAS tend to be reluctant to seek treatment. This study aims to explore use characteristics, treatment-seeking behaviour, side effects and associated health concerns among men with AAS use.

Bayesian networks in environmental and resource management.

This overview article for the special series, "Bayesian Networks in Environmental and Resource Management," reviews 7 case study articles with the aim to compare Bayesian network (BN) applications to different environmental and resource management problems from around the world. The article discusses advances in the last decade in the use of BNs as applied to environmental and resource management. We highlight progress in computational methods, best-practices for model design and model communication.

Use of Bayesian belief networks for dealing with ambiguity in integrated groundwater management.

In integrated groundwater management, different knowledge frames and uncertainties need to be communicated and handled explicitly. This is necessary in order to select efficient adaptive groundwater management strategies. In this connection, Bayesian belief networks allow for integration of knowledge, for engaging stakeholders and for dealing with multiple knowledge frame uncertainties.

An evolutionary Bayesian belief network methodology for participatory decision making under uncertainty: an application to groundwater management.

An integrated participatory approach based on Bayesian belief network (BBN) and evolutionary multiobjective optimization is proposed as an efficient decision-making tool in complex management problems. The proposed methodology incorporates all the available evidence and conflicting objectives to evaluate implications of alternative actions in the decision-making process and suggests best decision pathways under uncertainty. A BBN provides a framework within which the contributions of stakeholders can be taken into account.

Reflections on the use of Bayesian belief networks for adaptive management.

A broad range of tools are available for integrated water resource management (IWRM). In the EU research project NeWater, a hypothesis exists that IWRM cannot be realised unless current management regimes undergo a transition toward adaptive management (AM). This includes a structured process of learning, dealing with complexity, uncertainty etc.

Pain treatment on outpatient basis utilizing extradural opiates. A Danish multicentre study comprising 105 patients.

Previous to October 1st, 1981, 8 major Danish anaesthesiological departments registered 105 patients treated with extradural opiates for a period of more than 7 days, partially or completely on outpatient basis. Ninety-four suffered from painful malignant diseases and 11 patients from various painful benign diseases. The mean period of treatment was 65 days (range: 7-283 days) and of these 49 days (2-266 days) as outpatients.

Plasma morphine concentrations during chronic oral administration in patients with cancer pain.

Plasma concentrations of morphine were studied in 16 patients with chronic pain due to advanced cancer, treated with regular doses of morphine chloride by the oral route. Doses ranged from 20 to 125 mg every 4 h and a significant, positive, linear correlation was found between dose (range 0.22-3.