Publications by authors named "Hans H Ebert"

Article Synopsis
  • The study investigates the effectiveness of adaptive cardiac resynchronisation therapy (CRT) compared to conventional CRT in patients with heart failure and left bundle branch block, aiming to see if adaptive CRT provides better outcomes.
  • Conducted across 227 hospitals in 27 countries, the trial involved 3,797 patients who were randomized into two treatment groups, focusing on primary outcomes related to all-cause death and heart failure interventions.
  • The trial was halted early due to crossing the futility boundary, indicating that adaptive CRT did not demonstrate a significant benefit compared to conventional CRT after analyzing the data.
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Aims: The randomized, double-blind Third International Study on Syncope of Uncertain Etiology (ISSUE-3) showed that dual-chamber permanent pacing was effective in reducing the recurrence of syncope in patients ≥ 40 years with severe asystolic, probably neurally mediated syncope (NMS), documented by implantable loop recorder (ILR). Analysis in ISSUE-3 was performed according to the intention-to-treat principle. In the present study, we performed an on-treatment analysis, which included additionally those non-randomized patients followed up in the ISSUE registry to evaluate in a better manner the effectiveness of cardiac pacing therapy.

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Objective: According to the guidelines of the European Society of Cardiology, a presumed diagnosis of neurally mediated syncope (NMS) can be made when patients have a consistent history and competing diagnoses are excluded. In the present study, we compared the initial diagnosis of NMS by means of implantable loop recorder (ILR) documentation.

Methods: In this prospective multicentre observational study which involved 51 hospitals in nine countries in Europe and Canada, 504 NMS patients ≥40 years, who had suffered ≥3 syncopal episodes in the previous 2 years received an ILR and were followed up for a mean of 15±11 months.

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