Abnormal degree centrality in first-episode medication-free adolescent depression at rest: A functional magnetic resonance imaging study and support vector machine analysis.

Background: Depression in adolescents is more heterogeneous and less often diagnosed than depression in adults. At present, reliable approaches to differentiating between adolescents who are and are not affected by depression are lacking. This study was designed to assess voxel-level whole-brain functional connectivity changes associated with adolescent depression in an effort to define an imaging-based biomarker associated with this condition.