Publications by authors named "Hannush S"
Article Synopsis
- - Deep anterior lamellar keratoplasty (DALK) is a surgical technique for treating corneal disorders without affecting the endothelium, which helps prevent rejection and late graft failure compared to traditional penetrating keratoplasty (PK).
- - The introduction of the big-bubble technique (BBT) improved the efficiency and consistency of DALK by using air to separate corneal layers, resulting in high-quality grafts comparable to PK.
- - Understanding the anatomy behind BB formation, including the significance of Dua's layer, is essential for successful DALK procedures; ongoing improvements in BBT are increasing its use in corneal transplants with healthy endothelium.
Purpose Of Review: The Boston Keratoprosthesis Type 1 was pioneered by Claes Dohlman several decades ago. Since its inception, the device has undergone multiple revisions to address challenges associated with retroprosthetic membrane formation, retention, extrusion, stromal melt and endophthalmitis. Although visual outcomes and retention rates have improved, challenges, especially glaucoma, remain.
View Article and Find Full Text PDFImportance: Determining factors associated with endothelial cell loss after Descemet stripping automated endothelial keratoplasty (DSAEK) could improve long-term graft survival.
Objective: To evaluate the associations of donor, recipient, and operative factors with endothelial cell density (ECD) 3 years after DSAEK in the Cornea Preservation Time Study.
Design, Setting, And Participants: This cohort study was a secondary analysis of data collected in a multicenter, double-masked, randomized clinical trial.
Purpose: To review the graft survival rate, visual outcomes, and patient demographics of primary penetrating keratoplasty performed at Tenwek Hospital, a mission hospital in rural Kenya.
Methods: A retrospective review was performed of the clinical records of patients who underwent primary penetrating keratoplasty for optical purposes from January 2012 to October 2014. The graft survival rates were constructed using the Kaplan-Meier method, and the effect of clinical and socioeconomic characteristics on time to graft failure were examined using Cox regression models.
Purpose: To present a large case series of epithelial ingrowth or implantation following endothelial keratoplasty (EK) with the purpose of identifying the common causes as well as the various clinical presentations. We aim to determine the typical clinical course and the most effective treatment for this rare but serious complication.
Methods: This is a retrospective study of 13 patients who developed epithelial ingrowth or implantation post-EK.
Purpose: To describe the outcomes and prognostic characteristics of patients who had a repeat Boston type 1 keratoprosthesis (KPro) implantation.
Design: Retrospective case series.
Methods: setting: Data regarding preoperative clinical and demographic characteristics and postoperative course during initial and repeat KPro placement were collected at multiple centers across the country.
Purpose: To evaluate outcomes after Descemet stripping automated endothelial keratoplasty in eyes with glaucoma drainage devices.
Methods: This is a retrospective review of 24 cases performed by a single surgeon (S.B.
Purpose: To study the long-term outcomes of Boston type 1 keratoprosthesis (KPro) surgery.
Design: Retrospective, multicenter case series.
Participants: A total of 158 eyes of 150 patients underwent KPro implantation at 5 participating tertiary centers in the United States between January 2003 and December 2006.
Purpose: To report the first case series of patients with Fuchs corneal endothelial dystrophy (FCD) and keratoconus (KCN) who underwent Descemet stripping endothelial keratoplasty (DSEK).
Methods: This is a retrospective case series of 6 eyes of 4 patients with combined FCD and KCN who underwent DSEK at 3 different centers. Clinical information collected included corneal topography measurements, central corneal thickness, and endothelial cell count.
Importance: Endothelial morphometric measures have potential value in predicting graft failure after penetrating keratoplasty.
Objective: To determine whether preoperative and/or postoperative central morphometric measures (endothelial cell density [ECD], coefficient of variation [CV], and percentage of hexagonality [HEX]) and their postoperative changes are predictive of graft failure caused by endothelial decompensation after penetrating keratoplasty to treat a moderate-risk condition, principally Fuchs dystrophy or pseudophakic corneal edema.
Design: In a subset of Cornea Donor Study participants with graft failure, a central reading center determined preoperative and postoperative ECD, CV, and HEX from available central endothelial specular images.
Purpose: Descemet stripping automated endothelial keratoplasty (DSAEK) has its own set of complications including interface abnormalities. This case series presents the largest number of patients who developed textural interface opacity (TIO) at the graft-host interface after DSAEK.
Methods: This is a retrospective multicenter case series of 30 patients from 7 institutions with the finding of TIO.
Article Synopsis
- The study assesses graft dislocation rates in patients who had Descemet stripping automated endothelial keratoplasty (DSAEK) following a previous penetrating keratoplasty (PKP).
- Out of 97 eyes, 31% experienced graft dislocation post-surgery, with the majority requiring a rebubble to reattach.
- Risk factors identified for higher dislocation rates include donor grafts being smaller than the host and the presence of glaucoma drainage devices.
Purpose: To report the clinical and histopathological findings of 3 cases of late-onset deep infectious keratitis after Descemet stripping endothelial keratoplasty (DSEK) with vent incisions.
Methods: From a retrospective review of 150 consecutive patients who underwent uncomplicated DSEK with vent incisions, 3 patients developed late-onset deep infectious keratitis.
Results: In case 1, the patient suffered a Pseudomonas corneal ulcer at the nasal vent incision after a dacryocystorhinostomy with stent, 16 months after DSEK.
Purpose: To review 12 cases of postoperative detachment and spontaneous reattachment of Descemet stripping automated endothelial keratoplasty (DSAEK) lenticles.
Design: Retrospective, observational case series.
Methods: This was a review of patients undergoing DSAEK at 7 institutions.
Purpose: To report the outcomes of our experience with deep anterior lamellar keratoplasty (DALK) in patients with keratoconus.
Methods: A retrospective evaluation of 236 eyes of 198 patients that have undergone DALK between 2000 and 2006 using the Tsubota, Sugita, Melles, or Anwar technique. We analyzed the frequency of true Descemet membrane exposure, which we termed dDALK, and the number of eyes in which a predescemetic plane was achieved, which we termed pdDALK.
Purpose: To identify the genetic basis of posterior polymorphous corneal dystrophy (PPCD) through screening of four positional candidate genes and the COL8A2 gene, in which a presumed pathogenic mutation has previously been identified in affected patients.
Methods: DNA extraction, PCR amplification, and direct sequencing of the COL8A2, BFSP1, CST3, MMP9, and SLPI genes were performed in 14 unrelated, affected patients and in unaffected family members.
Results: In the COL8A2 gene, the previously identified, presumed pathogenic mutation (Gln455Lys) was not discovered in any of the affected patients.
Purpose: To describe a potentially serious complication of laser in situ keratomileusis (LASIK) that can masquerade as a persistent epithelial defect.
Setting: Refractive surgery centers in academic institutions.
Methods: Charts of 4 eyes in which epithelial-defect-masquerade syndrome was diagnosed were reviewed to determine the time to diagnosis and the presence of associated features that may have contributed to the delay in diagnosis.
Laser-in-situ-keratomileusis (LASIK) has become a popular technique of refractive surgery because of lower postoperative discomfort, early visual rehabilitation and decreased postoperative haze. Compared to photorefractive keratectomy (PRK), LASIK involves an additional procedure of creating a corneal flap. This may result in complications related to the flap, interface and underlying stromal bed.
View Article and Find Full Text PDFPurpose: To describe a series of cases (Elevated Intraocular Pressure Induced Interlamellar Stromal Keratitis (PISK)) that appears to be identical to post-laser in situ keratomileusis (LASIK) diffuse lamellar keratitis (DLK), but was present at a later time frame and was associated with a significant elevation of intraocular pressure (IOP). Unlike DLK, this syndrome is not steroid responsive, but resolves with a lowering of the IOP.
Design: Retrospective, noncomparative, small case series.
Sutured posterior chamber intraocular lenses: indications and procedure.
Curr Opin Ophthalmol
August 2000
Intraocular lens (IOL) implantation is the standard of care for treating aphakia when spectacle or contact lens correction is not viable. There is considerable controversy about the relative efficacy and safety of the different IOL implantation approaches, as well as their indications. Since the development of the modern, open-loop anterior chamber IOL (ACIOL) and the re-emergence of the iris-fixated claw IOL, ACIOL implantation for aphakia has regained popularity.
View Article and Find Full Text PDFPurpose: Meesmann corneal dystrophy is an autosomal dominant disorder characterized by fragility of the anterior corneal epithelium. We have previously demonstrated that this disease can be caused by mutations in the genes encoding keratins K3 or K12, the major intermediate filament proteins expressed in corneal epithelial cells. Here, we have carried out mutation analysis in a United States kindred presenting with typical features of Meesmann corneal dystrophy.
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