Publications by authors named "Hannon P"

: Social determinants of health (SDOH), such as food security and healthcare access, are key to maintaining and improving health. Publicly funded safety-net programs, such as Medicaid and the Supplemental Nutrition Assistance Program, address SDOH. Many low-wage employees are program-eligible, but there are substantial participation gaps.

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In 2022, the catchment area of the Fred Hutchinson/University of Washington/Seattle Children's Cancer Consortium (the Consortium) grew from 13-counties in Western Washington State to include all 39 counties in Washington. Widening the catchment area provided new opportunities for the Consortium to monitor the cancer burden, identify cancer-related health disparities, use a bidirectional approach to develop cancer focused programming, and facilitate research in clinical and community settings. In this commentary, we describe the exploratory process of catchment area change led by the Consortium's Office of Community Outreach and Engagement and new initiatives that followed that growth.

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This review describes employees working in low-wage industries in the United States, their health risks, and their access to health promotion and other health-related resources through their employers. We use publicly available datasets to illustrate how low-wage jobs affect employees' social determinants of health, health risk behaviors, and chronic conditions. We also discuss how the COVID-19 pandemic has shifted these employees' and employers' health-related priorities and work settings.

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  • * Most existing studies focus on single phthalate exposures in animal models, leaving the effects of real-life mixtures and their impacts on women's reproductive health largely unexamined.
  • * Recent literature indicates that high phthalate exposure is linked to menstrual irregularities, ovarian disorders, poor IVF outcomes, and adverse pregnancy results, highlighting the need for better research on phthalate mixtures and their mechanisms of toxicity.
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  • Engaging diverse partners throughout the research process enhances community-engaged research and adds value to implementation science, but there is a notable gap in partner involvement during dissemination stages, especially in writing peer-reviewed manuscripts.
  • The Implementation Science Centers in Cancer Control have adopted the Translational Science Benefits Model to illustrate their impact beyond traditional metrics by building community capacity and fostering engagement, with one center developing a policy to include community partners as coauthors.
  • A significant percentage (92%) of published papers from the center feature community coauthors, who play diverse roles and contribute to data interpretation and dissemination, ensuring that findings align with real-world practices and promote effective strategies for translating research into practice improvements.
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  • The cumulus-oocyte complex (COC) is important for ovulation, with its migratory abilities influenced by the expression of various proteases and their inhibitors.
  • In rats, human chorionic gonadotropin (hCG) significantly boosts the expression of specific proteases and inhibitors during ovulation, which can also be replicated with forskolin and ampiregulin in cultured COCs.
  • Comparative studies between rat and human COCs show differences in protease expression, suggesting that these enzymes are crucial for the migratory behavior of the COC at the time of ovulation.
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  • During the first year of the COVID-19 pandemic, some CDC-funded cancer screening programs managed to maintain screening volumes for breast and cervical cancer despite challenges posed by high state COVID-19 positivity rates.
  • A multi-case study involving 22 interviews highlighted the actions these successful programs took, such as streamlining administrative processes, enhancing patient safety protocols, and improving patient engagement through education and reminders.
  • The findings offer valuable insights for future emergency planning and routine operations in cancer screening and healthcare programs, emphasizing the importance of adaptability during crises.
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This paper will describe the case of a woman who presented with a rare condition called uterine arteriovenous malformation (AVM). A uterine AVM represents a connection between veins and arteries in the uterus. Clinicians should always consider this condition for a woman of childbearing age who presents with unexplained vaginal bleeding.

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Background: A Health Equity Task Force (HETF) of members from seven Centers funded by the National Cancer Institute's (NCI) Implementation Science in Cancer Control Centers (ISC) network sought to identify case examples of how Centers were applying a focus on health equity in implementation science to inform future research and capacity-building efforts.

Methods: HETF members at each ISC collected information on how health equity was conceptualized, operationalized, and addressed in initial research and capacity-building efforts across the seven ISC Centers funded in 2019-2020. Each Center completed a questionnaire assessing five health equity domains central to implementation science (e.

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Linguistically diverse communities face barriers to receiving appropriate health information. COVID-19 exacerbated these health-communication inequities. University of Washington researchers surveyed bilingual staff, students, and medical interpreters - desiring training to become effective communicators of COVID-19 information to their social networks and language communities.

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Purpose: Distal radioulnar joint (DRUJ) arthritis can cause painful and limited motion of the forearm leading to decreased function. When conservative treatment options are exhausted, surgical treatments are the next step. The purpose of this study was to retrospectively and prospectively evaluate outcomes of Scheker DRUJ total arthroplasty at a single center and add to the limited data on this procedure.

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Objective: The aim of the study is to explore tobacco-related knowledge and perceptions at Washington State (WA) agencies.

Methods: The study used a cross-sectional employee survey and qualitative focus groups with managers/supervisors. We produced descriptive statistics to examine differences in awareness and perceptions of tobacco-control efforts among employees and conducted a rapid thematic analysis of focus group data.

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Work is an important social determinant of health; unfortunately, work-related injuries remain prevalent, can have devastating impact on worker health, and can impose heavy economic burdens on workers and society. Occupational health services research (OHSR) underpins occupational health services policy and practice, focusing on health determinants, health services, healthcare delivery, and health systems affecting workers. The field of OHSR has undergone tremendous expansion in both definition and scope over the past 25 years.

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Basal cell carcinoma (BCC) is one of the most common skin malignancies in the United States. It commonly presents in the neck and head as a papulo-nodular lesion that is slow-growing with rare metastasis. BCC has a high curative rate often with Mohs surgery or excision of the lesion.

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Exposure to phthalates disrupts ovarian function. However, limited studies have investigated the effects of phthalate mixtures on ovulation, especially in women. Human granulosa cells were used to test the hypothesis that exposure to a phthalate mixture (PHTmix) disrupts progesterone (P4)/progesterone receptor (PGR) signaling, which is a crucial pathway for ovulation.

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Purpose: The Cancer Prevention and Control Research Network (CPCRN) is a national network focused on accelerating the translation of cancer prevention and control research evidence into practice through collaborative, multicenter projects in partnership with diverse communities. From 2003 to 2022, the CPCRN included 613 members.

Methods: We: (1) characterize the extent and nature of collaborations through a bibliometric analysis of 20 years of Network publications; and (2) describe key features and functions of the CPCRN as related to organizational structure, productivity, impact, and focus on health equity, partnership development, and capacity building through analysis of 22 in-depth interviews and review of Network documentation.

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Purpose: The COVID-19 pandemic has led to profound changes in the workplace as well as increases in stress, missed preventive care, and other health concerns. There is limited research since the onset of the pandemic on employees' primary health concerns and their willingness to engage with workplace health promotion (WHP) programs to address these needs. We conducted this survey about employees' current health priorities as a first step to exploring whether WHP programs need to evolve to be responsive to employees' needs at this stage of the pandemic.

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Purpose: To improve population health, community members need capacity (i.e., knowledge, skills, and tools) to select and implement evidence-based interventions (EBIs) to fit the needs of their local settings.

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  • Women with epilepsy (WWE) face significant risks during pregnancy, especially with medications like valproate, which can have harmful effects on both the mother and baby.
  • A study using the EpSMon app revealed that while awareness of pregnancy risks is somewhat higher among frequent users, overall risk awareness for pregnancy and sudden unexpected death in epilepsy (SUDEP) is still low.
  • There's a need for improved communication regarding these risks and better digital solutions, as current clinical approaches may not effectively meet the diverse needs of WWE.
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Colorectal cancer (CRC) screening reduces morbidity and mortality, but screening rates in the USA remain suboptimal. The Colorectal Cancer Control Program (CRCCP) was established in 2009 to increase screening among groups disproportionately affected. The CRCCP utilizes implementation science to support health system change as a strategy to reduce disparities in CRC screening by directing resources to primary care clinics to implement evidence-based interventions (EBIs) proven to increase CRC screening.

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  • High-dose interleukin-2 (HD IL-2) and pembrolizumab are FDA-approved treatments for metastatic melanoma, and this study aims to evaluate their combined safety.
  • In a Phase Ib trial, 10 patients received differing doses of IL-2 alongside pembrolizumab to determine the maximum tolerated dose (MTD).
  • Results showed that adverse events increased with higher IL-2 doses, but no serious toxicities were found, and one patient experienced a partial response, suggesting the combination is manageable and warrants further exploration.
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Background: In 2019-2020, with National Cancer Institute funding, seven implementation laboratory (I-Lab) partnerships between scientists and stakeholders in 'real-world' settings working to implement evidence-based interventions were developed within the Implementation Science Centers in Cancer Control (ISC3) consortium. This paper describes and compares approaches to the initial development of seven I-Labs in order to gain an understanding of the development of research partnerships representing various implementation science designs.

Methods: In April-June 2021, members of the ISC3 Implementation Laboratories workgroup interviewed research teams involved in I-Lab development in each center.

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Background: Embedding evidenced-based programs (EBPs) like PEARLS outside clinical settings can help reduce inequities in access to depression care. Trusted community-based organizations (CBOs) reach older adults who are underserved; however, PEARLS adoption has been limited. Implementation science has tried to close this know-do gap, however a more intentional focus on equity is needed to engage CBOs.

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Exposure to endocrine-disrupting chemicals (EDCs) is unavoidable, which represents a public health concern given the ability of EDCs to target the ovary. However, there is a large gap in the knowledge about the impact of EDCs on ovarian function, including the process of ovulation. Defects in ovulation are the leading cause of infertility in women, and EDC exposures are contributing to the prevalence of infertility.

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The luteinizing hormone (LH) surge induces paracrine mediators within the ovarian follicle that promote ovulation. The present study explores neurotensin (NTS), a neuropeptide, as a potential ovulatory mediator in the mouse ovary. Ovaries and granulosa cells (GCs) were collected from immature 23-day-old pregnant mare serum gonadotropin primed mice before (0 h) and after administration of human chorionic gonadotropin (hCG; an LH analog) across the periovulatory period (4, 8, 12, and 24 h).

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