Publications by authors named "Hannes van der Merwe"
Study protocol for two randomised controlled trials evaluating the effects of Cerclage in the reduction of extreme preterm birth and perinatal mortality in twin pregnancies with a short cervix or dilatation: the TWIN Cerclage studies.
Lissa van Gils Marjon A de Boer Judith Bosmans Ruben Duijnhoven Sam Schoenmakers Hannes van der Merwe
BMJ Open
May 2024
Article Synopsis
- Twin pregnancies face a high risk of extreme preterm birth (PTB) under 28 weeks, linked to serious health issues for newborns, and current treatments are limited.
- A potential solution is the placement of a vaginal cerclage for women with a short cervix or cervical dilatation, aiming to reduce the chances of extreme PTB.
- Two multicenter trials are planned in the Netherlands to evaluate the effectiveness of vaginal cerclage compared to standard care in these women, with specific recruitment goals and an analysis of costs and outcomes.
A dichloromethane extract from leaves of potentiated gamma aminobutyric acid-induced chloride currents by 171.8 ± 54% when tested at 100 µg/mL in oocytes transiently expressing gamma aminobutyric acid type A receptors composed of s subunits. In zebrafish larvae, the extract significantly lowered pentylenetetrazol-provoked locomotion when tested at 4 µg/mL.
View Article and Find Full Text PDF