Effects of CFTR-modulator triple therapy on sinunasal symptoms in children and adults with cystic fibrosis.

Purpose: Sinunasal symptoms and chronic rhinusinutitis are common in patients with cystic fibrosis. Cystic fibrosis transmembrane regulator (CFTR) modulators have led to dramatic improvements of respiratory symptoms and quality of life in patients with cystic fibrosis. This study aims to evaluate subjective and objective sinunasal symptoms after start of CFTR-modulator triple therapy.

A spiking neural program for sensorimotor control during foraging in flying insects.

Foraging is a vital behavioral task for living organisms. Behavioral strategies and abstract mathematical models thereof have been described in detail for various species. To explore the link between underlying neural circuits and computational principles, we present how a biologically detailed neural circuit model of the insect mushroom body implements sensory processing, learning, and motor control.

Numerical Cognition Based on Precise Counting with a Single Spiking Neuron.

Insects are able to solve basic numerical cognition tasks. We show that estimation of numerosity can be realized and learned by a single spiking neuron with an appropriate synaptic plasticity rule. This model can be efficiently trained to detect arbitrary spatiotemporal spike patterns on a noisy and dynamic background with high precision and low variance.

Area-specific processing of cerebellar-thalamo-cortical information in primates.

The cerebellar-thalamo-cortical (CTC) system plays a major role in controlling timing and coordination of voluntary movements. However, the functional impact of this system on motor cortical sites has not been documented in a systematic manner. We addressed this question by implanting a chronic stimulating electrode in the superior cerebellar peduncle (SCP) and recording evoked multiunit activity (MUA) and the local field potential (LFP) in the primary motor cortex ([Formula: see text]), the premotor cortex ([Formula: see text]) and the somatosensory cortex ([Formula: see text]).