The familial dysautonomia disease gene is required in the developing and adult mouse central nervous system.

Hereditary sensory and autonomic neuropathies (HSANs) are a genetically and clinically diverse group of disorders defined by peripheral nervous system (PNS) dysfunction. HSAN type III, known as familial dysautonomia (FD), results from a single base mutation in the gene that encodes a scaffolding unit (ELP1) for a multi-subunit complex known as Elongator. Since mutations in other Elongator subunits (ELP2 to ELP4) are associated with central nervous system (CNS) disorders, the goal of this study was to investigate a potential requirement for in the CNS of mice The sensory and autonomic pathophysiology of FD is fatal, with the majority of patients dying by age 40.

Relative laterality of the N170 to single letter stimuli is predicted by a concurrent neural index of implicit processing of letter names.

While previous research reports a consistently left-lateralized N170 to whole words relative to control stimuli, much less is known about the nature of single letter processing. Yet single letter processing is of both theoretical and practical interest, as letters form an initial unit of literacy learning for alphabetic scripts and may be particularly useful in the study of literacy development. In the present study, adult fluent readers completed an implicit processing one-back task while event-related brain potentials (ERPs) were recorded.