Publications by authors named "Hannah Slade"
Thermosensitive transient receptor potential V3 (TRPV3) is a polymodal receptor implicated in nociceptive, thermoceptive, pruritoceptive, and inflammatory pathways. Reports focused on understanding the role of TRPV3 in thermoception or nociception are not conclusive. Previous studies also show that aberrant hyperactivity of TRPV3 channels results in spontaneous itch and dermatitis-like symptoms, but the resultant behavior is highly dependent on the background of the animal and the skin microbiome.
View Article and Find Full Text PDFLightly stroking the lips or gently poking some skin regions can evoke mechanical itch in healthy human subjects. Sensitization of mechanical itch and persistent spontaneous itch are intractable symptoms in chronic itch patients. However, the underlying neural circuits are not well defined.
View Article and Find Full Text PDFArticle Synopsis
- Recent studies identify specific peripheral neurons for itch transmission, but spinal interneuron roles remain debated.
- Research shows that spinal somatostatin-positive (SOM) excitatory interneurons are crucial for transmitting itch sensations, as their ablation significantly reduces scratching responses to pruritogens.
- Findings suggest parallel pathways in spinal itch processing, highlighting a novel mechanism where SOM neurons influence itch perception through interactions with inhibitory interneurons.