Machine-learning based investigation of prognostic indicators for oncological outcome of pancreatic ductal adenocarcinoma.

Introduction: Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy with a poor prognosis. Surgical resection remains the only potential curative treatment option for early-stage resectable PDAC. Patients with locally advanced or micrometastatic disease should ideally undergo neoadjuvant therapy prior to surgical resection for an optimal treatment outcome.

Effect of bacterial contamination in bile on pancreatic cancer cell survival.

Background: Introduction of gut flora into the biliary system is common owing to biliary stenting in patients with obstructing pancreatic head cancer. We hypothesize that alteration of biliary microbiome modifies bile content that modulates pancreatic cancer cell survival.

Methods: Human bile samples were collected during pancreaticoduodenectomy.

Peritoneal Cell-Free Tumor DNA as Biomarker for Peritoneal Surface Malignancies.

Background: Disease burden in patients with peritoneal carcinomatosis (PC) is difficult to estimate. We evaluate whether peritoneal cell-free tumor DNA can be used as a measure of disease burden.

Patients And Methods: Malignant ascites or peritoneal lavage fluids were collected from patients with PC under approved IRB protocol.