Publications by authors named "Hannah R Hudson"
Background: An important hallmark of Alzheimer's Disease (AD) is the presence of neurofibrillary tangles (NFTs) composed of phosphorylated tau, which are commonly assessed using AT8 immunostains. Identifying additional markers to characterize the spectrum of NFT pathology is crucial for advancing our understanding and diagnosis of AD. This study introduces new potential markers to differentiate between tangles and healthy neurons.
View Article and Find Full Text PDFDefining and characterizing neuronal senescence, 'neurescence', as G arrested cells.
Trends Neurosci
December 2024
Article Synopsis
- - Cellular senescence is a state where cells resist dying and stop dividing, first seen in dividing cells but now recognized in non-dividing cells like neurons.
- - Confusion arises in understanding senescence in neurons because they can be in a quiescent (inactive) state, leading researchers to suggest a new term, 'neurescent,' for these senescent neurons.
- - The study proposes criteria to identify neurescent cells, explains their differences from quiescent neurons, and contrasts neurescent states with traditional senescence observed in dividing cells.