Publications by authors named "Hannah Morris Little"
The small freshwater cnidarian polyp uses adult stem cells (interstitial stem cells) to continually replace neurons throughout its life. This feature, combined with the ability to image the entire nervous system (Badhiwala et al., 2021; Dupre & Yuste, 2017) and availability of gene knockdown techniques (Juliano, Reich, et al.
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- The freshwater polyp's epithelial and interstitial stem cells are key models for studying stem cell evolution and function in animals.
- Researchers are focusing on understanding the transcriptional regulation that governs these stem cells and their differentiation into various cell types.
- New genomic resources, including updated RNA-seq data and chromatin interaction maps, have revealed new insights into gene regulation and identified previously uncharacterized cell types and potential regulatory factors conserved over millions of years.