Publications by authors named "Hannah Mathieson"
Objectives: This project aimed to determine whether cranial ischaemic complications at the presentation of giant cell arteritis (GCA) were associated with pre-existing cardiovascular (CV) risk factors, CV disease or genetic risk of CV-related traits.
Methods: 1946 GCA patients with clinicodemographic data at GCA presentation were included. Associations between pre-existing CV-related traits (including Polygenic Risk Scores (PRS) for CV traits) and cranial ischaemic complications were tested.
Objective: In polymyalgia rheumatica (PMR), glucocorticoids (GCs) relieve pain and stiffness, but fatigue may persist. We aimed to explore the effect of disease, GCs and PMR symptoms in the metabolite signatures of peripheral blood from patients with PMR or the related disease, giant cell arteritis (GCA).
Methods: Nuclear magnetic resonance spectroscopy was performed on serum from 40 patients with untreated PMR, 84 with new-onset confirmed GCA, and 53 with suspected GCA who later were clinically confirmed non-GCA, and 39 age-matched controls.
Article Synopsis
- The study explored how some patients with axial spondyloarthritis (axSpA) experience subjective symptom deterioration before their scheduled doses of three different TNF inhibitors (TNFis): etanercept, adalimumab, and infliximab.
- By analyzing MRI scans and clinical assessments, it was found that many patients showed high disease activity and a notable presence of bone marrow edema (MRI-BMO) before their doses.
- The results indicated that shorter periods between doses correlated with fewer new lesions and improved clinical responses, but further research is necessary to understand the implications of these findings.
Diurnal variation of gait in patients with rheumatoid arthritis: The DIVIGN study.
Clin Biomech (Bristol)
August 2014
Background: Circadian variation of joint stiffness (morning stiffness) and its impact on functional ability are widely recognised in rheumatoid arthritis. Subsequent within-day variation of walking ability is important due to the increased availability of instrumented gait analysis. This study aimed to quantify diurnal variation of gait in patients with rheumatoid arthritis, and explore associations with disease characteristics.
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