Publications by authors named "Hannah Lorenz"

Article Synopsis
  • ENPP1/CD203a is an enzyme that breaks down ATP and other nucleotides, influencing purinergic signaling and immune responses.
  • The study investigates ENPP1 expression on immune cells using new heavy-chain antibodies and finds high levels in specific cells like CD141 dendritic cells and natural killer cells, while most T cells and B cells show low expression.
  • This detailed analysis of ENPP1 expression will aid in understanding its role in immune regulation and could help identify ENPP1-related conditions and tumors for targeted treatments.
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Due to the novelty and high transmission rate of the coronavirus disease 2019 (COVID-19), direct medical countermeasures are urgently needed. Among actions against the further outbreak of COVID-19, vaccination has been considered as a chief candidate. However, the rapid development of COVID-19 vaccines has led to concern about their safety and thus to public vaccine hesitancy.

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In patients undergoing surgical resection of brain metastases, the risk of local recurrence remains high. Adjuvant whole brain radiation therapy (WBRT) can reduce the risk of local relapse but fails to improve overall survival. At two tertiary care centers in Germany, a retrospective study was performed to evaluate the role of hypofractionated stereotactic radiotherapy (HFSRT) in patients with brain metastases after surgical resection.

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Brain metastases show a recurrence rate of about 50% after surgical resection. Adjuvant radiotherapy can prevent progression; however, whole-brain radiotherapy (WBRT) can be associated with significant side effects. Local hypofractionated stereotactic radiotherapy (HFSRT) is a good alternative to provide local control with minimal toxicity.

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Objectives: The goal of this study is to evaluate the role of stereotactic fractionated radiotherapy (SFRT) in patients with one to three brain metastases after surgical resection.

Methods And Materials: We performed a retrospective single-institutional study in patients undergoing SFRT of surgical cavity after resection of ≤3 brain metastases. 60 patients with newly diagnosed brain metastases treated with SFRT following resection were included.

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