Publications by authors named "Hannah L Dixon"
Article Synopsis
- Upf1, typically studied for its role in mRNA decay, shows a significant association with active genes in the fission yeast Schizosaccharomyces pombe, as indicated by high-throughput ChIP data.
- This association is sensitive to RNase, correlates with RNA polymerase II (Pol II) transcription, and affects mRNA expression levels.
- In Upf1-deficient cells, there are notable changes in Pol II occupancy and an increased sensitivity to transcription elongation inhibitors, suggesting Upf1 may play a critical role in regulating gene transcription and Pol II phosphorylation.
Glycolysis is a fundamental metabolic pathway for glucose catabolism across biology, and glycolytic enzymes are among the most abundant proteins in cells. Their expression at such levels provides a particular challenge. Here we demonstrate that the glycolytic mRNAs are localized to granules in yeast and human cells.
View Article and Find Full Text PDFThe adhesion and spreading of cells onto the extracellular matrix (ECM) are essential cellular processes during organismal development and for the homeostasis of adult tissues. Interestingly, oxidative stress can alter these processes, thus contributing to the pathophysiology of diseases such as metastatic cancer. Therefore, understanding the mechanism(s) of how cells attach and spread on the ECM during perturbations in redox status can provide insight into normal and disease states.
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