Publications by authors named "Hannah Kozan"
Article Synopsis
- Zebrafish are valuable for researching lipid metabolism and related human disorders, but a standardized high-cholesterol diet (HCD) protocol for them was lacking.
- The study developed and tested a new HCD protocol, which led to notable hypercholesterolemia in the fish, indicated by increased levels of ApoB-containing lipoproteins and plasma cholesterol.
- Results showed that while larvae developed stable hepatic steatosis after being fed the HCD, adult zebrafish did not maintain the fatty liver phenotype but did exhibit elevated levels of ApoB-LPs and lipogenesis gene activity.
Article Synopsis
- Zebrafish are used as a model to study lipid metabolism and human lipid-related disorders, with a focus on the effects of a high-cholesterol diet (HCD).
- The study shows that feeding zebrafish an HCD leads to hypercholesterolemia and severe liver fat accumulation, even though liver fat increase isn't due to the typical pathways of fat production or breakdown.
- The findings suggest that the dietary cholesterol leads to fat buildup in fat cells, which in turn contributes to fatty liver conditions, making this protocol a useful tool for understanding cholesterol effects and fatty liver disease.
