Publications by authors named "Hannah K Pollard"
Article Synopsis
- Human lysine methyltransferase 2D (hKMT2D) helps "write" marks on proteins that affect how genes are used, but it needs help from a group called WRAD2 to work well.
- Studies showed that certain parts of WRAD2, like Ash2L and RbBP5, are super important for hKMT2D to do its job properly.
- Researchers found out how hKMT2D works with WRAD2 and discovered that it uses a special way to add different types of methyl marks on proteins, which helps control gene activity.
ATM (ataxia-telangiectasia mutated) is a phosphatidylinositol 3-kinase-related protein kinase (PIKK) best known for its role in DNA damage response. ATM also functions in oxidative stress response, insulin signaling, and neurogenesis. Our electron cryomicroscopy (cryo-EM) suggests that human ATM is in a dynamic equilibrium between closed and open dimers.
View Article and Find Full Text PDFMLK4 is a member of the mixed-lineage family of kinases that regulate the JNK, p38, and ERK kinase signaling pathways. MLK4 mutations have been identified in various human cancers, including frequently in colorectal cancer, where their function and pathobiological importance have been uncertain. In this study, we assessed the functional consequences of MLK4 mutations in colon tumorigenesis.
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