Publications by authors named "Hannah J Burden"
Objective: The minor allele (A) of the rs373863828 variant (p.Arg457Gln) in CREBRF is restricted to indigenous peoples of the Pacific islands (including New Zealand Māori and peoples of Polynesia), with a frequency of up to 25% in these populations. This allele associates with a large increase in body mass index (BMI) but with significantly lower risk of type-2 diabetes (T2D).
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- The study investigates how the A allele of the rs373863828 gene affects insulin release and sensitivity in overweight/obese men of Māori and Pacific ancestry, particularly its relationship with body mass index (BMI) and diabetes risk.
- Results indicate that men with the A allele have a greater increase in plasma insulin after meals, but this does not impact their insulin sensitivity or glucose disposal rates.
- The findings suggest that the A allele could contribute to a reduced risk of type 2 diabetes by enhancing insulin release without compromising insulin sensitivity.
Background: The ability to measure insulin secretion from pancreatic beta cells and monitor glucose-insulin physiology is vital to current health needs. C-peptide has been used successfully as a surrogate for plasma insulin concentration. Quantifying the expected variability of modelled insulin secretion will improve confidence in model estimates.
View Article and Find Full Text PDFObjective: Model-based metabolic tests require accurate identification of subject-specific parameters from measured assays. Insulin assays are used to identify insulin kinetics parameters, such as general and first-pass hepatic clearances. This study assesses the impact of intravenous insulin boluses on parameter identification precision.
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