Midwife continuity of care models versus other models of care for childbearing women.

Background: Midwives are primary providers of care for childbearing women globally and there is a need to establish whether there are differences in effectiveness between midwife continuity of care models and other models of care. This is an update of a review published in 2016.

Objectives: To compare the effects of midwife continuity of care models with other models of care for childbearing women and their infants.

A Central Small RNA Regulatory Circuit Controlling Bacterial Denitrification and NO Emissions.

Global atmospheric loading of the climate-active gas nitrous oxide (NO) continues to increase. A significant proportion of anthropogenic NO emissions arises from microbial transformation of nitrogen-based fertilizers during denitrification, making microbial NO emissions a key target for greenhouse gas reduction strategies. The genetic, physiological, and environmental regulation of microbially mediated NO flux is poorly understood and therefore represents a critical knowledge gap in the development of successful mitigation approaches.

Direct Oral Anticoagulants for Thromboprophylaxis in Patients with Antiphospholipid Syndrome.

The current mainstay of the treatment and secondary thromboprophylaxis of thrombotic antiphospholipid syndrome (APS) is anticoagulation with warfarin or other vitamin K antagonists (VKAs). In addition to their well-known limitations, VKAs are often problematic in APS patients because of the variable sensitivity of thromboplastins to lupus anticoagulant. As a result, the international normalized ratio may not accurately reflect the intensity of anticoagulation.