Intravascular donor monocytes play a central role in lung transplant ischaemia-reperfusion injury.

Rationale: Primary graft dysfunction in lung transplant recipients derives from the initial, largely leukocyte-dependent, ischaemia-reperfusion injury. Intravascular lung-marginated monocytes have been shown to play key roles in experimental acute lung injury, but their contribution to lung ischaemia-reperfusion injury post transplantation is unknown.

Objective: To define the role of donor intravascular monocytes in lung transplant-related acute lung injury and primary graft dysfunction.