Publications by authors named "Hannah Ebert"
A primary obstacle in translating genetic associations with disease into therapeutic strategies is elucidating the cellular programs affected by genetic risk variants and effector genes. Here, we introduce LipocyteProfiler, a cardiometabolic-disease-oriented high-content image-based profiling tool that enables evaluation of thousands of morphological and cellular profiles that can be systematically linked to genes and genetic variants relevant to cardiometabolic disease. We show that LipocyteProfiler allows surveillance of diverse cellular programs by generating rich context- and process-specific cellular profiles across hepatocyte and adipocyte cell-state transitions.
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- Recent studies have linked a genetic risk for type 2 diabetes with a lower likelihood of accumulating body fat, paralleling traits seen in metabolically obese normal weight (MONW) individuals.
- Researchers identified a specific genetic variant (rs6712203) in the COBLL1 gene that influences gene expression and affects how fat cells grow and store lipids, leading to difficulties in developing proper adipose tissue.
- Using mouse models, they demonstrated that altering the COBLL1 gene mirrors MONW traits, including reduced body fat and impaired glucose regulation, highlighting a potential target for future diabetes treatments and understanding of genetic influences on metabolism.