Publications by authors named "Hannah E Stumpf"
Article Synopsis
- Cholangiocarcinoma (CCA) is a challenging type of cancer with poor immune response and survival rates, necessitating advanced mouse models to study its tumor microenvironment and immune evasion strategies.
- The study developed new immunocompetent mouse models of intrahepatic CCA (iCCA) that accurately replicate human disease, allowing researchers to analyze tumor genomics and immune characteristics.
- Results showed that different genetic mouse models exhibited unique tumor mutation patterns and immune responses, highlighting the need for varied preclinical models to effectively test immunotherapy treatments.
Background & Aims: Proapoptotic tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) signaling as a cause of cancer cell death is a well-established mechanism. However, TRAIL-receptor (TRAIL-R) agonists have had very limited anticancer activity in human beings, challenging the concept of TRAIL as a potent anticancer agent. Herein, we aimed to define mechanisms by which TRAIL cancer cells can leverage noncanonical TRAIL signaling in myeloid-derived suppressor cells (MDSCs) promoting their abundance in murine cholangiocarcinoma (CCA).
View Article and Find Full Text PDFProapoptotic tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) signaling as a cause of cancer cell death is a well-established mechanism. However, TRAIL-receptor (TRAIL-R) agonists have had very limited anticancer activity in humans, challenging the concept of TRAIL as a potent anticancer agent. Herein, we demonstrate that TRAIL cancer cells can leverage noncanonical TRAIL signaling in myeloid-derived suppressor cells (MDSCs) promoting their abundance in murine cholangiocarcinoma (CCA).
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