Publications by authors named "Hannah E Joyce"
Article Synopsis
- Older adults with heart failure are at increased risk for Alzheimer’s disease and related dementia, potentially influenced by insomnia and depression.
- This study analyzed data from over 203,000 Veterans to determine how insomnia and depressive episodes affect the timing of dementia diagnosis.
- Findings showed that patients with both insomnia and depression had the quickest progression to dementia, highlighting the need for screening these conditions to improve early detection and intervention.
Article Synopsis
- The study explores the need for non-invasive methods to detect amyloid-β pathology in Alzheimer’s disease, especially with new treatments available.
- It evaluates the effectiveness of plasma tau phosphorylated at threonine-217 (P-tau217) as a potential alternative for determining eligibility for DMTs like aducanumab.
- Results indicate that elevated P-tau217 levels strongly predict Aβ positivity, suggesting that this method could efficiently identify candidates for treatment while also highlighting the complexity of cutoff levels needed for accurate diagnoses.
Article Synopsis
- The study investigates non-invasive methods for detecting amyloid-β pathology in early Alzheimer's disease, focusing on the use of plasma tau phosphorylated at threonine-217 (P-tau217) as a potential alternative to costly and invasive techniques like PET and CSF analysis.
- Researchers developed specific P-tau217 cutoffs and tested them on candidates from a memory and aging program, using ROC analysis to assess diagnostic accuracy against established methods.
- Results showed high predictive accuracy of P-tau217 for identifying Aβ positivity, with a significant portion of candidates being treated with aducanumab, indicating that these cutoff strategies could improve access to disease-modifying treatments.
Contributions of brain glutamate (Glu) to conscious emotion are not well understood. Here, we evaluate the relationship of experimentally induced change in neocortical Glu (ΔGlu) and subjective states in well individuals, using combined application of pharmacological challenge, magnetic resonance spectroscopy (MRS), and comprehensive affective assessment. Drug challenge with d-amphetamine (AMP) (20 mg oral), methamphetamine (MA) (Desoxyn, 20 mg oral), and placebo (PBO) was conducted on three separate test days in a within-subjects double blind design.
View Article and Find Full Text PDFContributions of brain glutamate to conscious emotion are not well understood. Here we evaluate the relationship of experimentally-induced change in neocortical glutamate (ΔGlu) and subjective states in well individuals. Drug challenge with -amphetamine (AMP; 20 mg oral), methamphetamine (MA; Desoxyn, 20 mg oral), and placebo (PBO) was conducted on three separate test days in a within-subjects double blind design.
View Article and Find Full Text PDFIntroduction: Repetitive Transcranial magnetic stimulation (rTMS) is an FDA approved treatment for major depressive disorder (MDD). However, neural mechanisms contributing to rTMS effects on depressive symptoms, cognition, and behavior are unclear. Proton magnetic resonance spectroscopy (MRS), a noninvasive neuroimaging technique measuring concentrations of biochemical compounds within the brain in vivo, may provide mechanistic insights.
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